Response of aspirin-allergic patients to challenge by some analgesics in common use.

British medical journal ·Vol. 2 ·No. 5760 ·1971-05-29 ·Pages 494-6

Smith AP

Abstract

Challenge tests with some analgesics in common use were performed in five aspirin-sensitive asthmatics. Marked falls in FEV(1) were observed after ingestion of paracetamol, indomethacin, mefenamic acid, and dextropropoxyphene in some subjects. The mechanisms of analgesic-induced asthma are discussed: it is believed to be a non-immunological process of great practical importance when prescribing analgesics to asthmatics.

MeSH Terms

Acetaminophen/adverse effects Adult Analgesics/adverse effects Aspirin/adverse effects Asthma/chemically induced Dextropropoxyphene/adverse effects Drug Hypersensitivity Female Humans Indomethacin/adverse effects Male Mefenamic Acid/adverse effects Middle Aged Spirometry

Chemicals

Analgesics Acetaminophen Mefenamic Acid Aspirin Dextropropoxyphene Indomethacin

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Smith A P

References (12)

12 references, click to expand

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Antagonism by aspirin and fenamates of bronchoconstriction and nociception induced by adenosine-5'-triphosphate.
Nature. 1966 Oct 22;212(5060):411-2 PMID: 4381910
Adrenergic receptors viewed in light of general receptor theories.
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Concerning the nature of intolerance to aspirin.
J Allergy. 1967 Nov;40(5):281-93 PMID: 5235203
Intolerance to aspirin. Clinical studies and consideration of its pathogenesis.
Ann Intern Med. 1968 May;68(5):975-83 PMID: 5646829
Antagonism by fenamates and like-acting drugs of bronchoconstriction induced by bradykinin or antigen in the guinea-pig.
Br J Pharmacol. 1968 Sep;34(1):76-87 PMID: 5676040
New therapy in bronchial asthma. An evaluation of ponstel (mefenamic acid) in chronic bronchial asthma and pulmonary emphysema.
J Kans Med Soc. 1968 Oct;69(10):474-8 PMID: 5705538
Aspirin intolerance and asthma. A clinical and immunological study.
Ann Intern Med. 1969 Sep;71(3):479-96 PMID: 4185641
Hypersensitivity to aspirin: clinical and immunological studies.
Helv Med Acta. 1969 Nov;35(2):86-95 PMID: 5363014
Analgesic antipyretic drugs as antagonists of bradykinin.
Br J Pharmacol Chemother. 1960 Dec;15:601-10 PMID: 13694701
Anti-asthmatic effect of phenazone and amidopyrine.
Nature. 1961 Dec 16;192:1089-90 PMID: 13906947
Antagonism by mefenamic and flufenamic acids of the bronchoconstrictor action of kinins in the guinea-pig.
Br J Pharmacol Chemother. 1963 Apr;20:345-51 PMID: 14022332

Article Info

Journal

British medical journal

Abbr.

Br Med J

ISSN

0007-1447

DOI

10.1136/bmj.2.5760.494

Published

1971-05-29

Pages

494-6

Language

English

Region

England

NLM ID

0372673

PMCID

PMC1796028

Subset

External Links

PubMed source DOI: 10.1136/bmj.2.5760.494 PMC Full Text

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Response of aspirin-allergic patients to challenge by some analgesics in common use.

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