Prostaglandins and glaucoma.

British medical journal ·Vol. 3 ·No. 5775 ·1971-09-11 ·Pages 615-7

Wyllie AM, Wyllie JH

Abstract

Human aqueous humour was found to contain a substance which contracted the rat stomach strip. The mean activity was significantly higher in specimens from open angle glaucoma cases than in specimens from patients with cataract. The pharmacological and chromatographic properties of the active material were studied in aqueous humour obtained from cadavers; activity seemed to be due to prostaglandin E(1). These results suggest that prostaglandin E(1) may play some part in the aetiology of open angle glaucoma.

MeSH Terms

Aged Aqueous Humor/analysis Biological Assay Cadaver Cataract/metabolism Chromatography, Thin Layer Female Glaucoma/etiology,metabolism Humans Male Middle Aged Prostaglandins/analysis Stomach

Chemicals

Prostaglandins

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Wyllie A M

Wyllie J H

References (5)

5 references, click to expand

Prostaglandin influences on intraocular pressure and pupil size.
Am J Physiol. 1967 Feb;212(2):329-34 PMID: 6018014
The effects of prostaglandins on the intraocular pressure of the rabbit.
Br J Pharmacol. 1969 Sep;37(1):158-67 PMID: 4981000
A sensitive method for the assay of 5-hydroxytryptamine.
Br J Pharmacol Chemother. 1957 Sep;12(3):344-9 PMID: 13460242
Further studies on the preparation, purification and nature of irin.
J Physiol. 1959 May 19;146(2):255-94 PMID: 13655231
EFFECT OF MECHANICAL STIMULATION ON RABBITS' EYES: RELEASE OF ACTIVE SUBSTANCE IN ANTERIOR CHAMBER PERFUSATES.
J Physiol. 1965 Feb;176:378-408 PMID: 14289827

Article Info

Journal

British medical journal

Abbr.

Br Med J

ISSN

0007-1447

DOI

10.1136/bmj.3.5775.615

Published

1971-09-11

Pages

615-7

Language

English

Region

England

NLM ID

0372673

PMCID

PMC1798780

Subset

External Links

PubMed source DOI: 10.1136/bmj.3.5775.615 PMC Full Text

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