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PMID: 556785 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Macromolecular synthesis in cells infected by frog virus 3. VI. Frog virus 3 replication is dependent on the cell nucleus.

Journal of virology ·Vol. 21 ·No. 2 ·1977-02-00 ·Pages 802-5

Goorha R, Willis DB, Granoff A

Abstract

Previous evidence indicated that frog virus 3 (FV3), an icosahedral DNA virus, replicates exclusively in the cytoplasm. However, data presented here demonstrate that FV3 does not replicate in UV-irradiated or enuleated chicken embryo or BSC-1 cells and that virus-specific DNA synthesis is not initiated in such cells. Primary transcription was not detected in infected enucleated cells. These results demonstrate that a functional nucleus is essential for FV3 replication.

MeSH Terms
Animals Anura/microbiology Cell Line Cell Nucleus/metabolism,microbiology,radiation effects DNA Viruses/growth & development,metabolism DNA, Viral/biosynthesis RNA, Viral/biosynthesis Ultraviolet Rays Virus Replication
Chemicals
DNA, Viral RNA, Viral
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Goorha R
Willis D B
Granoff A
References (11)
11 references, click to expand
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    Virology. 1971 May;44(2):286-95 PMID: 5105771
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.21.2.802-805.1977
Published
1977-02-00
Pages
802-5
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC353883
Subset
IM
External Links
PubMed source DOI: 10.1128/JVI.21.2.802-805.1977 PMC Full Text View journal details
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