Progeria: a cell culture study on aging.

The Journal of clinical investigation ·Vol. 50 ·No. 9 ·1971-09-00 ·Pages 2000-3

Danes BS

Abstract

Progeria is an autosomal recessive disorder showing precocious senility. The cultured skin fibroblast from both the homozygous affected individual and the heterozygous parents can be distinguished from normals by decreased cell growth in culture. Mitotic activity, DNA synthesis, and cloning efficiency are markedly reduced.

MeSH Terms

Aging Clone Cells Culture Techniques Cytogenetics DNA/biosynthesis Female Fibroblasts/metabolism Genes, Recessive Heterozygote Homozygote Humans Male Mitosis Progeria/genetics,metabolism Skin/cytology Thymidine/metabolism Tritium Werner Syndrome

Chemicals

Tritium DNA Thymidine

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Danes B S

References (15)

15 references, click to expand

Hurler's syndrome. A genetic study in cell culture.
J Exp Med. 1966 Jan 1;123(1):1-16 PMID: 4159251
Werner's syndrome; caricature of aging. A genetic model for the study of degenerative diseases.
Trans Assoc Am Physicians. 1965;78:73-81 PMID: 5864984
Werner's syndrome a review of its symptomatology, natural history, pathologic features, genetics and relationship to the natural aging process.
Medicine (Baltimore). 1966 May;45(3):177-221 PMID: 5327241
Lifespan of cultured cells in progeria.
Lancet. 1969 Feb 22;1(7591):424 PMID: 4179275
Cystic fibrosis of the pancreas. A study in cell culture.
J Exp Med. 1969 Apr 1;129(4):775-93 PMID: 4237349
Viability of human diploid cells as a function of in vitro age.
J Cell Physiol. 1969 Dec;74(3):219-22 PMID: 5358258
Lymphocyte transformation in vitro measured by tritiated thymidine uptake. I. Lymphocyte culture techniques.
Int Arch Allergy Appl Immunol. 1970;37(5):506-31 PMID: 5410777
Diabetes mellitus and aging: diminished planting efficiency of cultured human fibroblasts.
Proc Natl Acad Sci U S A. 1969 Sep;64(1):155-60 PMID: 5262997
Replicative life-span of cultivated human cells. Effects of donor's age, tissue, and genotype.
Lab Invest. 1970 Jul;23(1):86-92 PMID: 5431223
Human chromosome complements in normal somatic cells in culture.
Am J Hum Genet. 1959 Mar;11(1):63-79 PMID: 13626937
The serial cultivation of human diploid cell strains.
Exp Cell Res. 1961 Dec;25:585-621 PMID: 13905658
Preparation of poliovirus vaccines in a human fetal diploid cell strain.
Am J Hyg. 1962 Mar;75:240-58 PMID: 13905660
THE LIMITED IN VITRO LIFETIME OF HUMAN DIPLOID CELL STRAINS.
Exp Cell Res. 1965 Mar;37:614-36 PMID: 14315085
Clonal growth of mammalian cells in vitro; growth characteristics of colonies from single HeLa cells with and without a feeder layer.
J Exp Med. 1956 Feb 1;103(2):273-83 PMID: 13286432
Progeria, a pathologic study.
J Pediatr. 1960 Jul;57:70-7 PMID: 13825821

Article Info

Journal

The Journal of clinical investigation

Abbr.

J Clin Invest

ISSN

0021-9738

DOI

10.1172/JCI106692

Published

1971-09-00

Pages

2000-3

Language

English

Region

United States

NLM ID

7802877

PMCID

PMC292126

Subset

External Links

PubMed source DOI: 10.1172/JCI106692 PMC Full Text View journal details

Analysis Services

Progeria: a cell culture study on aging.

Contact

WeChat Official Account