Acetylcholine binding to Torpedo electroplax: relationship to acetylcholine receptors.

Science (New York, N.Y.) ·Vol. 173 ·No. 3994 ·1971-07-23 ·Pages 338-40

Eldefrawi ME, Britten AG, Eldefrawi AT

Abstract

Binding of [(3)H]acetylcholine to a particulate fraction of Torpedo electroplax was measured by equilibrium dialysis. Two high-affinity sites present on phospholipoproteins bound acetylcholine reversibly, and binding was blocked by nicotinic drugs. Characteristics of this binding suggest that these phospholipoproteins may be acetylcholine receptors.

MeSH Terms

Acetylcholine/antagonists & inhibitors,metabolism Animals Decamethonium Compounds/metabolism Dialysis Eels Electric Organ/metabolism Erythrocytes/drug effects Lipoproteins/metabolism Macromolecular Substances Nicotinic Acids/pharmacology Protein Binding/drug effects Receptors, Cholinergic Receptors, Drug Tubocurarine/metabolism

Chemicals

Decamethonium Compounds Lipoproteins Macromolecular Substances Nicotinic Acids Receptors, Cholinergic Receptors, Drug Acetylcholine Tubocurarine

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Eldefrawi M E

Britten A G

Eldefrawi A T

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.173.3994.338

Published

1971-07-23

Pages

338-40

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.173.3994.338 View journal details

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Acetylcholine binding to Torpedo electroplax: relationship to acetylcholine receptors.

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