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LiteratureArticle Details
PMID: 5556579
Published · ppublish
English
Journal Article
Transplacental carcinogenesis by stilbestrol.
Abstract
暂无摘要
Keywords
Adolescent Pregnancy
Adolescents
Adolescents
Female
Age Factors
Biology
Cancer
Contraceptive Agents
Estrogen
Demographic Factors
Diethylstilbestrol--contraindications
Diethylstilbestrol--side effects
Diseases
Endocrine System
Estrogens
Hormones
Maternal-fetal Exchange
Neoplasms
Oral Contraceptives
Physiology
Population
Population Characteristics
Pregnancy
Reproduction
Vaginal Cancer--etiology
Youth
MeSH Terms
Adenocarcinoma/chemically induced,prevention & control
Age Factors
Carcinogens
Diethylstilbestrol/adverse effects,metabolism
Female
Humans
Maternal-Fetal Exchange
Pregnancy
Pregnancy Complications/drug therapy
Vaginal Neoplasms/chemically induced,prevention & control
Chemicals
Carcinogens
Diethylstilbestrol
Other Abstracts
eng
This editorial argues the cause-and-effect relationship between in utero exposure to diethylstilbestrol (DES) and incidence of vaginal adenocarcinoma among young women. It is conjectured that the mechanism by which DES induces tumors is a result of transplacental carcinogenesis
i.e., DES causes a malignant change in any fetal cell of future vaginal tissue, resulting in a genetic defect which may not be realized until puberty, when endogenous hormone production acts as a promoter of the malignancy initiated by DES exposure during gestation. If this theory is correct, local progestational therapy may arrest future adenocarcinoma cases. Though it is obvious that DES therapy must be avoided in the future in the population of pregnant women, of more concern is the presence of residual DES in foodstuffs, particularly livestock meat. A ban of such diet supplementation of human foodstuffs is called for.
Article Info
Journal
The New England journal of medicine
Abbr.
N Engl J Med
ISSN
0028-4793
Published
1971-08-12
Pages
404-5
Language
English
Region
United States
NLM ID
0255562
Subset
IM
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