5-fluorocytosine and urinary candidiasis.

British medical journal ·Vol. 1 ·No. 5749 ·1971-03-13 ·Pages 577-9

Davies RR, Reeves DS

Abstract

Two patients with urinary candidiasis were treated with 5-fluorocytosine. Serum levels of the drug and a study of its excretion in urine are recorded together with a brief account of its activity in body fluids. Evidence of toxicity was not observed with dosages of from 2 to 5 g a day.

MeSH Terms

Aged Body Fluids/analysis Candidiasis/drug therapy Cytosine/analysis,blood,therapeutic use,toxicity,urine Female Fluorides/analysis,blood,therapeutic use,toxicity,urine Humans Male Middle Aged Protein Binding Urinary Tract Infections/drug therapy

Chemicals

Cytosine Fluorides

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Davies R R

Reeves D S

References (13)

13 references, click to expand

In vitro studies with 5-fluorocytosine.
Appl Microbiol. 1969 Jun;17(6):871-7 PMID: 5797940
CLINICAL LABORATORY DIAGNOSIS OF URINARY TRACT INFECTIONS.
J Urol. 1965 Jul;94:78-81 PMID: 14319478
Fungus infections of the urinary tract.
Yale J Biol Med. 1958 Feb;30(4):292-305 PMID: 13531169
Acute monilial pyohydronephrosis: report of a case successfully treated with amphotericin B continuous renal pelvis irrigation.
J Urol. 1966 Nov;96(5):614-8 PMID: 5923283
Factors affecting serum inhibited growth of Candida albicans and Cryptococcus neoformans.
Sabouraudia. 1969 Oct;7(3):219-29 PMID: 5385158
Human serum interactions with Candida albicans.
J Immunol. 1968 Jul;101(1):128-32 PMID: 4173934
Disseminated, fatal postpartum candidiasis with renal suppuration: case report.
J Urol. 1956 Jun;75(6):930-6 PMID: 13320589
Torulopsis glabrata septicaemia treated with 5-fluorocytosine.
Lancet. 1970 Apr 18;1(7651):839-40 PMID: 4191461
Further in vitro studies with 5-fluorocytosine.
Infect Immun. 1970 Oct;2(4):484-8 PMID: 16557866
The metabolism of 5-fluorocytosine-2-14-C and of cytosine-14-C in the rat and the disposition of 5-fluorocytosine-2-14-C in man.
Biochem Pharmacol. 1966 Apr;15(4):435-46 PMID: 5955812
Monilial cystitis-effective treatment with instilations of amphotericin B.
JAMA. 1960 Sep 24;174:359-62 PMID: 13706544
Candida endocarditis treated with 5-fluorocytosine.
Br Med J. 1971 Jan 30;1(5743):262-4 PMID: 5212581
Some aspects of the absorption, distribution, and excretion of amphotericin B in man.
Antibiotic Med Clin Ther (New York). 1958 May;5(5):295-301 PMID: 13521767

Article Info

Journal

British medical journal

Abbr.

Br Med J

ISSN

0007-1447

DOI

10.1136/bmj.1.5749.577

Published

1971-03-13

Pages

577-9

Language

English

Region

England

NLM ID

0372673

PMCID

PMC1795260

Subset

External Links

PubMed source DOI: 10.1136/bmj.1.5749.577 PMC Full Text

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5-fluorocytosine and urinary candidiasis.

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