Home LiteratureArticle Details
PMID: 5542614 Published · ppublish English Journal Article

Membrane current noise in lobster axon under voltage clamp.

Biophysical journal ·Vol. 11 ·No. 2 ·1971-02-00 ·Pages 211-34

Poussart DJ

Abstract

Random fluctuations in the steady-state current of neural membrane were measured in the giant lobster axon by means of a low noise voltage-clamp system. The power density spectrum S(f) of the fluctuations was evaluated between 20 and 5120 Hz and found to be of the type 1/f. Mean values of the potassium, sodium, and leakage currents I(K), I(Na), and I(L) were also measured by usual voltage-clamp techniques. Comparisons between these two types of data recorded under a number of different experimental conditions, such as presence of tetrodotoxin (TTX), substitution of calcium by lanthanum, and changes in the external concentration of potassium, have strongly suggested that the intensity of the fluctuations is related to the magnitude of I(K).

MeSH Terms
Animals Axons/drug effects,physiology Calcium/pharmacology Crustacea
Chemicals
Calcium
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Poussart D J
References (26)
26 references, click to expand
  1. Ionic conductance changes in lobster axon membrane when lanthanum is substituted for calcium.
    J Gen Physiol. 1966 Nov;50(2):461-71 PMID: 11526840
  2. SODIUM, POTASSIUM, AND CHLORIDE CONCENTRATIONS AND FLUXES IN THE ISOLATED GIANT AXON OF HOMARUS.
    J Neurophysiol. 1965 Jul;28:742-72 PMID: 14347632
  3. Alkali cation selectivity of squid axon membrane.
    Ann N Y Acad Sci. 1966 Jul 14;137(2):818-29 PMID: 5229831
  4. Membrane watching.
    J Gen Physiol. 1968 May 1;51(5):1-7 PMID: 19873576
  5. Excitation of the squid axon membrane in isosmotic potassium chloride.
    Nature. 1959 Jan 24;183(4656):265-6 PMID: 13622770
  6. The time dependence of single file diffusion.
    Biophys J. 1967 Sep;7(5):545-54 PMID: 6048877
  7. Membrane potentials of the lobster giant axon obtained by use of the sucrose-gap technique.
    J Gen Physiol. 1962 Jul;45:1195-216 PMID: 14452759
  8. Effect of tetrodotoxin on the early outward currents in perfused giant axons.
    Proc Natl Acad Sci U S A. 1967 May;57(5):1350-5 PMID: 5231740
  9. Axon membrane voltage fluctuations.
    Acta Physiol Pharmacol Neerl. 1965-1966;13(4):373-466 PMID: 5883687
  10. Blockage of sodium conductance increase in lobster giant axon by tarichatoxin (tetrodotoxin).
    J Gen Physiol. 1966 May;49(5):977-88 PMID: 5961361
  11. The N-shaped current-potential characteristic in frog skin. II. Kinetic behavior during ramp voltage clamp.
    Biophys J. 1969 Feb;9(2):140-50 PMID: 5764224
  12. Fluctuations of resting neural membrane potential.
    Science. 1966 Mar 18;151(3716):1388-9 PMID: 5909786
  13. Current-voltage relations in the lobster giant axon membrane under voltage clamp conditions.
    J Gen Physiol. 1962 Jul;45:1217-38 PMID: 14452758
  14. Amplitude distribution of axon membrane noise voltage.
    Acta Physiol Pharmacol Neerl. 1969 Aug;15(3):353-79 PMID: 5808653
  15. Removal of potassium negative resistance in perfused squid giant axons.
    J Gen Physiol. 1967 Jul;50(6):1499-515 PMID: 6034755
  16. Competitive action of calcium and procaine on lobster axon. A study of the mechanism of action of certain local anesthetics.
    J Gen Physiol. 1966 May;49(5):1043-63 PMID: 5961353
  17. Prolonged action potentials from single nodes of Ranvier.
    J Gen Physiol. 1958 Sep 20;42(1):137-62 PMID: 13575778
  18. Synaptic noise and other sources of randomness in motoneuron interspike intervals.
    J Neurophysiol. 1968 Jul;31(4):574-87 PMID: 5709873
  19. Interspike interval fluctuations in aplysia pacemaker neurons.
    Biophys J. 1966 Jul;6(4):411-34 PMID: 19210968
  20. Slow changes of potassium permeability in the squid giant axon.
    Biophys J. 1966 Sep;6(5):553-66 PMID: 5970562
  21. DDT: interaction with nerve membrane conductance changes.
    Science. 1967 Sep 22;157(3795):1438-40 PMID: 6037859
  22. TETRODOTOXIN BLOCKAGE OF SODIUM CONDUCTANCE INCREASE IN LOBSTER GIANT AXONS.
    J Gen Physiol. 1964 May;47:965-74 PMID: 14155438
  23. The action of calcium on the electrical properties of squid axons.
    J Physiol. 1957 Jul 11;137(2):218-44 PMID: 13449874
  24. Nerve membrane current noise: direct measurements under voltage clamp.
    Proc Natl Acad Sci U S A. 1969 Sep;64(1):95-9 PMID: 5263026
  25. Fluctuations in excitability of single myelinated nerve fibres.
    Experientia. 1964 Oct 15;20(10):553-4 PMID: 5859211
  26. Statistical analysis and functional interpretation of neuronal spike data.
    Annu Rev Physiol. 1966;28:493-522 PMID: 5323104
Article Info
Journal
Biophysical journal
Abbr.
Biophys J
ISSN
0006-3495
DOI
10.1016/S0006-3495(71)86209-4
Published
1971-02-00
Pages
211-34
Language
English
Region
United States
NLM ID
0370626
PMCID
PMC1484018
Subset
IM
External Links
PubMed source DOI: 10.1016/S0006-3495(71)86209-4 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2