Abstract
1. The ability of tricarboxylic acid-cycle metabolites to influence the physiological performance of the perfused anaerobic rat heart was investigated. Energy expenditure/h [(beats/min)x60xsystolic pressure/g of protein] for various anoxic conditions compared with oxygenated control hearts were: 5mm-glucose, 4.5%; 20mm- or 40mm-glucose, 10%; 20mm-glucose plus fumerate+malate+glutamate, 29%; 20mm-glucose plus oxaloacetate and alpha-oxoglutarate, 31%. 2. The energy expenditure/lactate production ratio was increased by the tricarboxylic acid-cycle metabolites, indicating that alterations in anaerobic physiological performance did not result from changes in glycolysis. 3. Analysis of tissue constituents provided further indication of an enhanced energy status for fumarate+malate+glutamate- and oxaloacetate+alpha-oxoglutarate-perfused hearts; tissue concentrations of both glycogen and ATP were higher than in the 20mm-glucose-perfused groups. 4. A marked increase in the accumulation of succinate in tissues perfused with oxaloacetate+alpha-oxoglutarate or fumarate+malate+glutamate provided further evidence that these metabolites were stimulating mitochondrial energy production under anoxia. 5. These studies indicate that mitochondrial ATP production can be stimulated in an isolated mammalian tissue perfused under anaerobiosis with a resulting enhancement of cell function.
MeSH Terms
Adenosine Triphosphate/metabolism
Animals
Citric Acid Cycle
Fumarates/pharmacology
Glucose/pharmacology
Glutamates/pharmacology
Glycogen/metabolism
Glycolysis
Heart/drug effects,physiology
Heart Rate
Hypoxia/metabolism,physiopathology
In Vitro Techniques
Ketoglutaric Acids/pharmacology
Lactates/biosynthesis
Malates/pharmacology
Male
Metabolism
Myocardium/analysis,metabolism
Oxaloacetates/pharmacology
Oxygen/pharmacology
Perfusion
Phosphocreatine/metabolism
Rats
Succinates/metabolism
Chemicals
Fumarates
Glutamates
Ketoglutaric Acids
Lactates
Malates
Oxaloacetates
Succinates
Phosphocreatine
Adenosine Triphosphate
Glycogen
Glucose
Oxygen
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Penney D G
Cascarano J
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14 references, click to expand
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