Two-step binding of eukaryotic ribosomes to brome mosaic virus RNA3.

Nature ·Vol. 281 ·No. 5729 ·1979-09-27 ·Pages 277-82

Ahlquist P, Dasgupta R, Shih DS, Zimmern D, Kaesberg P

Abstract

Although brome mosaic virus RNA3 has only one translatable cistron, it can bind two 80S ribosomes at initiation. One ribosome binds at the first AUG codon (base 92-94). The other binds nearer the 5' end at an entry or holding site. Disome formation is thus unrelated to a silent cistron approximately 1,000 bases downstream.

MeSH Terms

Base Sequence Binding Sites Cell-Free System Codon Mosaic Viruses/genetics Nucleic Acid Conformation Peptide Chain Initiation, Translational RNA, Messenger/metabolism RNA, Viral/metabolism Ribosomes/metabolism

Chemicals

Codon RNA, Messenger RNA, Viral

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Ahlquist P

Dasgupta R

Shih D S

Zimmern D

Kaesberg P

Article Info

Journal

Nature

Abbr.

Nature

ISSN

0028-0836

DOI

10.1038/281277a0

Published

1979-09-27

Pages

277-82

Language

English

Region

England

NLM ID

0410462

Subset

External Links

PubMed source DOI: 10.1038/281277a0 View journal details

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Two-step binding of eukaryotic ribosomes to brome mosaic virus RNA3.

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