Studies of the effect of metoclopramide and apomorphine on gastric emptying and secretion in man.

Gut ·Vol. 11 ·No. 12 ·1970-12-00 ·Pages 989-93

Ramsbottom N, Hunt JN

Abstract

With oral and intravenous doses of metoclopramide there was no constant effect on the gastric emptying of test meals of glucose or sodium citrate, nor was secretion of acid by the stomach in response to test meals of glucose or sodium citrate affected. Apomorphine, in subnauseous doses (0.25 mg intravenously) slowed the gastric emptying of test meals containing sodium citrate, and 10 mg of intravenous metoclopramide abolished the slowing of gastric emptying caused by apomorphine.

MeSH Terms

Amides/pharmacology Apomorphine/pharmacology Benzoates/pharmacology Citrates Gastric Juice/metabolism Gastric Mucosa/metabolism Gastrointestinal Motility/drug effects Glucose Humans Injections, Intravenous Male Secretory Rate/drug effects Stomach/drug effects,physiology

Chemicals

Amides Benzoates Citrates Glucose Apomorphine

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Ramsbottom N

Hunt J N

References (10)

10 references, click to expand

Gastric emptying and secretion in man.
Physiol Rev. 1959 Jul;39(3):491-533 PMID: 13674903
The regulation of gastric emptying of meals containing citric acid and salts of citric acid.
J Physiol. 1962 Aug;163:34-45 PMID: 14450029
Physiology and pharmacology of vomiting.
Pharmacol Rev. 1953 Jun;5(2):193-230 PMID: 13064033
The osmotic effects of some simple molecules and ions on gastric emptying.
J Physiol. 1960 Dec;154(2):254-69 PMID: 16992067
Metoclopramide ('Maxolon')--a new anti-emetic.
Br J Clin Pract. 1967 Sep 9;21(9):457-60 PMID: 4864490
Action of insulin hypoglycemia on motor and secretory functions of the digestive tract.
Physiol Rev. 1953 Oct;33(4):566-92 PMID: 13100071
Radiological observations of stomach changes accompanying threat of injection in a sample of peptic ulcer patients.
Psychosom Med. 1955 Jan-Feb;17(1):56-61 PMID: 13237389
Action of metoclopramide on gastric emptying and small bowel transit time.
Gut. 1968 Apr;9(2):203-5 PMID: 5655030
The action of "metoclopramide" on gastric emptying: a radiological assessment.
Med J Aust. 1966 Dec 31;2(27):1272-4 PMID: 5957603
Gastrointestinal effects of metoclopramide in man. In vitro experiments with human smooth muscle preparations.
Br Med J. 1968 Dec 14;4(5632):679-80 PMID: 5723387

Article Info

Journal

Gut

Abbr.

Gut

ISSN

0017-5749

DOI

10.1136/gut.11.12.989

Published

1970-12-00

Pages

989-93

Language

English

Region

England

NLM ID

2985108R

PMCID

PMC1553172

Subset

External Links

PubMed source DOI: 10.1136/gut.11.12.989 PMC Full Text View journal details

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Studies of the effect of metoclopramide and apomorphine on gastric emptying and secretion in man.

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