Inhibition of catecholamine Uptake-2 by steroids in the isolated rat heart.

British journal of pharmacology ·Vol. 40 ·No. 3 ·1970-11-00 ·Pages 528-30

Iversen LL, Salt PJ

Abstract

Various steroids (17-beta-oestradiol, corticosterone, deoxycorticosterone, progesterone, testosterone and androsterone) produced a dose-dependent inhibition of the uptake of (3)H-noradrenaline by the Uptake(2) mechanism in the isolated perfused heart. It is suggested that these results may explain the potentiating effects of such steroids on the responses of vascular smooth muscle to catecholamines.

MeSH Terms

Androsterone/pharmacology Animals Blood Vessels/drug effects Corticosterone/pharmacology Depression, Chemical Desoxycorticosterone/pharmacology

Chemicals

Desoxycorticosterone Androsterone Corticosterone

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Iversen L L

Salt P J

References (5)

5 references, click to expand

Mechanism of hydrocortisone potentiation of responses to epinephrine and norepinephrine in rabbit aorta.
Circ Res. 1969 Mar;24(3):383-95 PMID: 5766517
Steroid potentiation of responses to sympathomimetic amines in aortic strips.
Br J Pharmacol. 1969 Jul;36(3):582-93 PMID: 5789811
The role of uptake2 in the extraneuronal metabolism of catecholamines in the isolated rat heart.
Br J Pharmacol. 1969 Nov;37(3):638-49 PMID: 5348467
The influence of the adrenal cortex on behavior of terminal vascular bed.
Ann N Y Acad Sci. 1953 Jul 17;56(4):626-33 PMID: 13208053
A UNIFIED THEORY OF GLUCOCORTICOID ACTION.
Perspect Biol Med. 1964;7:71-84 PMID: 14215618

Article Info

Journal

British journal of pharmacology

Abbr.

Br J Pharmacol

ISSN

0007-1188

DOI

10.1111/j.1476-5381.1970.tb10637.x

Published

1970-11-00

Pages

528-30

Language

English

Region

England

NLM ID

7502536

PMCID

PMC1703119

Subset

External Links

PubMed source DOI: 10.1111/j.1476-5381.1970.tb10637.x PMC Full Text View journal details

Analysis Services

Inhibition of catecholamine Uptake-2 by steroids in the isolated rat heart.

Contact

WeChat Official Account