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PMID: 5481516 Published · ppublish English Journal Article

Serum fibrin-fibrinogen degradation products associated with postoperative pulmonary embolus and venous thrombosis.

British medical journal ·Vol. 4 ·No. 5732 ·1970-11-14 ·Pages 395-8

Ruckley CV, Das PC, Leitch AG, Donaldson AA, Copland WA, Redpath AT, Scott P, Cash JD

Abstract

A total of 76 "high-risk" surgical patients were studied for evidence of venous thromboembolic disease. Episodes of deep vein thrombosis and of pulmonary embolism were related to changes in blood levels of fibrin degradation products (F.D.P.). When diagnosed either by ordinary clinical means or by venography and isotope scanning significantly raised F.D.P. levels were found in all cases. Serum F.D.P. estimations are unlikely to help in detecting deep vein thrombosis, but may prove valuable in diagnosing pulmonary embolism.

MeSH Terms
Adult Aged Female Fibrin/analysis,metabolism Fibrinogen/analysis,metabolism Humans Iodine Radioisotopes Male Middle Aged Phlebography Postoperative Complications Pulmonary Embolism/blood,diagnosis,diagnostic imaging,metabolism Radionuclide Imaging Thrombophlebitis/blood,diagnosis,diagnostic imaging,metabolism
Chemicals
Iodine Radioisotopes Fibrin Fibrinogen
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Ruckley C V
Das P C
Leitch A G
Donaldson A A
Copland W A
Redpath A T
Scott P
Cash J D
References (24)
24 references, click to expand
  1. Treatment of pulmonary embolic disease. A critical review of some aspects of current therapy.
    N Engl J Med. 1965 Oct 21;273(17):885-92 PMID: 5319289
  2. [A new method for the determination of fibrinolytic activity by means of immunoassay of breakdown products of fibrin and fibrinogen].
    Rinsho Byori. 1965 Oct;13(10):542-8 PMID: 5894847
  3. Quantitative estimation of split products of fibrinogen in human serum, relation to diagnosis and treatment.
    Blood. 1966 Jul;28(1):1-18 PMID: 5944259
  4. Ultrasonic flow detection. A useful technic in the evaluation of peripheral vascular disease.
    Am J Surg. 1967 Mar;113(3):311-20 PMID: 6018677
  5. Pulmonary embolism.
    Annu Rev Med. 1967;18:443-58 PMID: 5337534
  6. The angiographic diagnosis of acute pulmonary embolism: evaluation of criteria.
    Am Heart J. 1967 Jun;73(6):730-41 PMID: 6028602
  7. Reflected ultrasound in the study of diseases of the chest.
    Trans Am Clin Climatol Assoc. 1967;78:28-37 PMID: 6029333
  8. Fibrin degradation products in sera of normal subjects.
    Br Med J. 1967 Dec 23;4(5581):718-20 PMID: 6060821
  9. The post-mortem incdence of pulmonary embolism in a hospital population.
    Br J Surg. 1968 May;55(5):347-52 PMID: 5648012
  10. Comparison of clinical and Doppler ultrasound evaluation of confirmed lower extremity venous disease.
    Surgery. 1968 Jul;64(1):332-8 PMID: 5658736
  11. Ferric hydroxide particles labeled with indium in 113m for lung scanning.
    JAMA. 1968 Oct 7;206(2):339-43 PMID: 5695606
  12. The diagnosis of deep-vein thrombosis in the leg using 125-I-Fibrinogen.
    Br J Surg. 1968 Nov;55(11):825-30 PMID: 5686975
  13. 125-I-labelled fibrinogen in the diagnosis of deep-vein thrombosis and its correlation with phlebography.
    Br J Surg. 1968 Nov;55(11):835-9 PMID: 5688647
  14. Diagnosis of suspected or occult pulmonary embolus.
    Br Med J. 1969 May 31;2(5656):576 PMID: 5769896
  15. Fibrin-fibrinogen degradation products in sera of normal infants and children.
    Arch Dis Child. 1969 Dec;44(238):761-4 PMID: 5356984
  16. The adsorption of proteins on erythrocytes treated with tannic acid and subsequent hemagglutination by antiprotein sera.
    J Exp Med. 1951 Feb;93(2):107-20 PMID: 14803635
  17. Venous thrombosis of the lower limbs with particular reference to bed-rest.
    Br J Surg. 1957 Nov;45(191):209-36 PMID: 13510687
  18. [Analysis, by immuno-chemical methods, of the degradation by plasmin of human fibrinogen and fibrin, at different stages].
    Nouv Rev Fr Hematol. 1960 Nov-Dec;15:451-66 PMID: 13729935
  19. Venous thrombosis and pulmonary embolism. A clinico-pathological study in injured and burned patients.
    Br J Surg. 1961 Mar;48:475-89 PMID: 13750445
  20. PULMONARY EMBOLISM.
    Br Med J. 1963 Oct 5;2(5361):830-5 PMID: 14063921
  21. DIAGNOSIS OF MASSIVE PULMONARY EMBOLISM IN MAN BY RADIOISOTOPE SCANNING.
    N Engl J Med. 1964 Aug 20;271:377-84 PMID: 14164654
  22. PULMONARY THROMBOEMBOLISM--THE CASE FOR THE PULMONARY ANGIOGRAM.
    Am J Roentgenol Radium Ther Nucl Med. 1964 Sep;92:693-8 PMID: 14217089
  23. FREQUENCY OF PULMONARY THROMBOEMBOLISM IN MAN.
    N Engl J Med. 1965 Jun 17;272:1278-80 PMID: 14290550
  24. Pathogenesis of the coagulation defect developing during pathological plasma proteolytic ("fibrinolytic") states. II. The significance, mechanism and consequences of defective fibrin polymerization.
    J Clin Invest. 1962 Apr;41:917-34 PMID: 13860492
Article Info
Journal
British medical journal
Abbr.
Br Med J
ISSN
0007-1447
DOI
10.1136/bmj.4.5732.395
Published
1970-11-14
Pages
395-8
Language
English
Region
England
NLM ID
0372673
PMCID
PMC1819952
Subset
IM
External Links
PubMed source DOI: 10.1136/bmj.4.5732.395 PMC Full Text
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