The role of phosphate in the secretion of parathyroid hormone in man.
In man, oral administration of 1 g of phosphorus resulted in a 60-125% increase in serum immunoassayable parathyroid hormone (PTH) concentration. Peak PTH levels were attained in 1 hr, and PTH returned to base line levels in 2 hr. This increase in PTH appeared to be initiated by a very small decrease of total and ionized calcium and was abolished by a calcium infusion. There was no correlation between serum phosphorus and PTH. The experiments show that oral phosphorus administration initiates a calcium-mediated control system for PTH secretion and that this system operates very sensitively in man.
11 references, click to expand
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Application of radioimmunoassay to differentiation of adenoma and hyperplasia and to preoperative localization of hyperfunctioning parathyroid glands.N Engl J Med. 1969 Jun 19;280(25):1381-5 PMID: 5771363
-
Regulation of parathyroid hormone secretion: proportional control by calcium, lack of effect of phosphate.Endocrinology. 1968 Nov;83(5):1043-51 PMID: 4971855
-
Experience with a radioimmunoassay of parathyroid hormone in human sera.Trans Assoc Am Physicians. 1968;81:104-15 PMID: 5721395
-
Parathyroid hormone in plasma in adenomatous hyperparathyroidism, uremia, and bronchogenic carcinoma.Science. 1966 Nov 18;154(3751):907-9 PMID: 4975444
-
Caclium, phosphorus, and bone in renal disease and transplantation.Arch Intern Med. 1969 May;123(5):543-53 PMID: 4888973
-
IMMUNOASSAY OF BOVINE AND HUMAN PARATHYROID HORMONE.Proc Natl Acad Sci U S A. 1963 May;49(5):613-7 PMID: 16591075
-
Phosphate homeostasis: sensitivity of parathyroid-mediated response of renal excretion.J Lab Clin Med. 1962 Mar;59:387-95 PMID: 14476227
-
Ionized calcium in normal serum, ultrafiltrates, and whole blood determined by ion-exchange electrodes.J Clin Invest. 1970 Feb;49(2):318-34 PMID: 4983663
-
Immunochemical heterogeneity of parathyroid hormone in plasma.J Clin Endocrinol Metab. 1968 Jul;28(7):1037-47 PMID: 5660255
-
Effect of calcium on parathyroid secretion.Endocrinology. 1965 Oct;77(4):725-30 PMID: 5842797
-
A radioimmunoassay for parathyroid hormone in man.Proc Soc Exp Biol Med. 1968 Jun;128(2):501-4 PMID: 5663263
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