Isoantigenic variants: isolation from human diploid cells in culture.

Science (New York, N.Y.) ·Vol. 168 ·No. 3929 ·1970-04-17 ·Pages 370-2

Adman R, Pious DA

Abstract

Variant human fibroblast substrains, resistant to a cytotoxic human isoantiserum, were isolated from sensitive strains by repeated exposure to isoantiserum and rabbit complement. The resistant phenotype was stable, apparently occurred at low frequency, and was associated with loss of surface isoantigens.

MeSH Terms

Animals Complement System Proteins Culture Techniques Diploidy Fibroblasts/immunology Humans Immune Sera Isoantigens/isolation & purification Rabbits

Chemicals

Immune Sera Isoantigens Complement System Proteins

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Adman R

Pious D A

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.168.3929.370

Published

1970-04-17

Pages

370-2

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.168.3929.370 View journal details

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Isoantigenic variants: isolation from human diploid cells in culture.

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