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PMID: 5411446 Published · ppublish English Clinical Trial Comparative Study Controlled Clinical Trial Journal Article

Comparison of cardiorespiratory effects of isoprenaline and salbutamol in patients with bronchial asthma.

British medical journal ·Vol. 1 ·No. 5688 ·1970-01-10 ·Pages 65-70

Warrell DA, Robertson DG, Howes JN, Conolly ME, Paterson JW, Beilin LJ, Dollery CT

Abstract

The effects of isoprenaline and salbutamol administered orally, by inhalation, or by intravenous infusion were compared in 13 asthmatic patients. Bronchodilator activity was assessed by serial measurement of specific airways conductance (SGaw). Log-dose response curves were obtained for both drugs and showed them to be equipotent as bronchodilators. Cardiovascular effects were variable, but in general, isopenaline caused greater rise in pulse rate and a greater change in blood pressure than the same dose of salbutamol.Cardiorespiratory measurements during continuous intravenous infusion of increasing doses of both drugs suggested a greater effect of isoprenaline than the same dose of salbutamol on metabolic rate, pulmonary ventilation, pulmonary gas exchange, cardiac output, and heart rate. The effect of salbutamol on the heart rate was about 10 times less than that of isoprenaline but lasted longer.

MeSH Terms
Adult Aged Alcohols/administration & dosage Asthma/drug therapy,metabolism Blood Pressure/drug effects Bronchodilator Agents/administration & dosage Cardiac Output/drug effects Female Heart/drug effects Heart Rate/drug effects Humans Isoproterenol/administration & dosage Male Middle Aged Pulse/drug effects Respiration/drug effects
Chemicals
Alcohols Bronchodilator Agents Isoproterenol
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Warrell D A
Robertson D G
Howes J N
Conolly M E
Paterson J W
Beilin L J
Dollery C T
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19 references, click to expand
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Article Info
Journal
British medical journal
Abbr.
Br Med J
ISSN
0007-1447
Published
1970-01-10
Pages
65-70
Language
English
Region
England
NLM ID
0372673
PMCID
PMC1699164
Subset
IM
External Links
PubMed source PMC Full Text
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