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PMID: 5410848 Published · ppublish English Journal Article

Tolerance to polyinosinic-polycytidylic acid in NZB-NZW mice.

Science (New York, N.Y.) ·Vol. 167 ·No. 3919 ·1970-02-06 ·Pages 870-1

Steinberg AD, Daley GG, Talal N

Abstract

Immunological tolerance to polyinosinic * polycytidylic acid was induced in NZB/ NZW mice. This is the first experimental induction of tolerance to a nucleic antigen.

MeSH Terms
Animals Antibody Formation/drug effects Cyclophosphamide/pharmacology Cytosine Nucleotides/pharmacology Disease Models, Animal Immune Tolerance/drug effects Lupus Erythematosus, Systemic/immunology Mice Nucleic Acids/pharmacology Polynucleotides/pharmacology RNA/chemical synthesis
Chemicals
Cytosine Nucleotides Nucleic Acids Polynucleotides RNA Cyclophosphamide
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Steinberg A D
Daley G G
Talal N
Article Info
Journal
Science (New York, N.Y.)
Abbr.
Science
ISSN
0036-8075
DOI
10.1126/science.167.3919.870
Published
1970-02-06
Pages
870-1
Language
English
Region
United States
NLM ID
0404511
Subset
IM
External Links
PubMed source DOI: 10.1126/science.167.3919.870 View journal details
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