Inhibition of morphine tolerance and physical dependence development and brain serotonin synthesis by cycloheximide.

Allyl Compounds/pharmacology Animals Body Weight Brain/metabolism Carbon Isotopes Chromatography, Thin Layer Cycloheximide/administration & dosage,pharmacology Drug Tolerance/drug effects Ethers, Cyclic/pharmacology Female Humans Injections, Intraperitoneal Injections, Intravenous Injections, Subcutaneous Kidney/analysis Liver/analysis Male Mice Morphinans/pharmacology Morphine/administration & dosage,antagonists & inhibitors,blood,metabolism,pharmacology Morphine Dependence/metabolism,mortality,prevention & control Pargyline/pharmacology Serotonin/biosynthesis,metabolism Time Factors

Allyl Compounds Carbon Isotopes Ethers, Cyclic Morphinans Serotonin Morphine Cycloheximide Pargyline