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题目:: Functional subdivision of islets of Langerhans and possible role of D cells.
作者:: Orci(L),Unger(R H)
状态:: 发布时间1976-02-13 , 更新时间 2015-06-16
期刊:: Lancet
摘要:: Immunocytochemical examination of the islets of Langerhans in various animal species, including man, indicates that insulin-producing cells (B cells), glucagon-producing cells (A cells), and cells producing somatostatin or a somatostatin-like peptide (D cells) are not randomly arranged within the islet. Whenever A cells are found in the islet--i.e., mostly in its peripheral part--they are accompanied by D cells. However, most B cells, which occupy a central position, are in contact only with other B cells. In view of the inhibitory effect of somatostatin on both insulin and glucagon secretion, it is suggested that the arrangement of A, B and D cells is important to the normal and pathological functioning of the islet.
语言:: eng
DOI:

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