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PMID: 5359607 Published · ppublish English Journal Article

Characteristics of virulent, attenuated, and avirulent Mycoplasma pneumoniae strains.

Journal of bacteriology ·Vol. 100 ·No. 2 ·1969-11-00 ·Pages 1037-43

Lipman RP, Clyde WA, Denny FW

Abstract

Homologous pairs of virulent and attenuated or avirulent Mycoplasma pneumoniae strains were derived and compared in an effort to elucidate the mechanisms of virulence. These related strains were found to vary in growth, glycolysis, protein electrophoretic patterns, peroxide formation, morphology, and cytadsorption. Variations in the last two characteristics closely correlated with avirulence. This enables understanding of one stage in the pathogenic sequence and provides a convenient marker for avirulence. The derivation of infectious avirulent strains may make possible their use as live vaccines against M. pneumoniae disease.

MeSH Terms
Animals Bacterial Proteins/analysis Chick Embryo Complement Fixation Tests Cricetinae Culture Media Electrophoresis Microscopy, Electron Mycoplasma/analysis,classification,cytology,growth & development,immunology,pathogenicity Mycoplasma Infections/therapy Vaccines Virulence
Chemicals
Bacterial Proteins Culture Media Vaccines
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Lipman R P
Clyde W A
Denny F W
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24 references, click to expand
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Article Info
Journal
Journal of bacteriology
Abbr.
J Bacteriol
ISSN
0021-9193
DOI
10.1128/jb.100.2.1037-1043.1969
Published
1969-11-00
Pages
1037-43
Language
English
Region
United States
NLM ID
2985120R
PMCID
PMC250191
Subset
IM
External Links
PubMed source DOI: 10.1128/jb.100.2.1037-1043.1969 PMC Full Text View journal details
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