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PMID: 534517 Published · ppublish English Journal Article

A cartilage catabolic factor from synovium.

The Biochemical journal ·Vol. 184 ·No. 1 ·1979-10-15 ·Pages 177-80

Dingle JT, Saklatvala J, Hembry R, Tyler J, Fell HB, Jubb R

Abstract

Porcine synovium in organ culture produces a factor that causes chondrocytes to degrade their matrix. A quantitative assay for the factor, for which the cartilage of bovine nasal septum is used, is described. Evidence is presented that the catabolic factor is a protein.

MeSH Terms
Animals Biological Assay/methods Cartilage, Articular/drug effects,metabolism Cattle Chemical Fractionation Culture Techniques Proteins/analysis,isolation & purification,pharmacology Swine Synovial Membrane/analysis
Chemicals
Proteins
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Dingle J T
Saklatvala J
Hembry R
Tyler J
Fell H B
Jubb R
References (6)
6 references, click to expand
  1. VIRUS-CELL INTERACTION WITH A TUMOR-PRODUCING VIRUS.
    Proc Natl Acad Sci U S A. 1960 Mar;46(3):365-70 PMID: 16578494
  2. Protein measurement with the Folin phenol reagent.
    J Biol Chem. 1951 Nov;193(1):265-75 PMID: 14907713
  3. Breakdown of proteoglycan and collagen induced in pig articular cartilage in organ culture.
    Ann Rheum Dis. 1975 Aug;34(4):303-11 PMID: 127555
  4. The effect of synovial tissue on the breakdown of articular cartilage in organ culture.
    Arthritis Rheum. 1977 Sep-Oct;20(7):1359-71 PMID: 911354
  5. Chicken alpha2-proteinase inhibitor: a serum protein homologous with ovoinhibitor of egg white.
    Biochim Biophys Acta. 1974 Nov 5;371(1):52-62 PMID: 4214561
  6. Heberden oration 1978. Recent studies on the control of joint damage: the contribution of the Strangeways Research Laboratory.
    Ann Rheum Dis. 1979 Jun;38(3):201-14 PMID: 485574
Article Info
Journal
The Biochemical journal
Abbr.
Biochem J
ISSN
0264-6021
DOI
10.1042/bj1840177
Published
1979-10-15
Pages
177-80
Language
English
Region
England
NLM ID
2984726R
PMCID
PMC1161690
Subset
IM
External Links
PubMed source DOI: 10.1042/bj1840177 PMC Full Text View journal details
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