Cholinergic mechanisms in the caudate nucleus.

The Journal of physiology ·Vol. 187 ·No. 1 ·1966-11-00 ·Pages 163-75

McLennan H, York DH

Abstract

1. Acetylcholine (ACh), and a number of cholinomimetic and cholinolytic agents, have been applied to single neurones of the caudate nucleus, and the effects compared with those produced by stimulation of nucleus ventralis anterior thalami (VA).2. Neurones responding by excitation following ACh and VA stimulation, and others depressed by both ACh and VA stimulation have been observed. The two types of cell are located in different regions of the nucleus.3. Both types of ACh effect, and the responses to VA stimulation, are prevented by atropine.4. Taken with the earlier observation that the release of ACh from the caudate can be enhanced by VA stimulation, it has been suggested that the present results indicate a final cholinergic link in the pathway from VA to caudate.

MeSH Terms

Acetylcholine/pharmacology Action Potentials Animals Atropine/pharmacology Cats Caudate Nucleus/drug effects,physiology Electric Stimulation Iontophoresis Methacholine Compounds/pharmacology Neurons/drug effects,physiology Quaternary Ammonium Compounds/pharmacology Stereotaxic Techniques Synapses/drug effects Thalamus/physiology

Chemicals

Methacholine Compounds Quaternary Ammonium Compounds Atropine Acetylcholine

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

McLennan H

York D H

References (16)

16 references, click to expand

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Article Info

Journal

The Journal of physiology

Abbr.

J Physiol

ISSN

0022-3751

DOI

10.1113/jphysiol.1966.sp008080

Published

1966-11-00

Pages

163-75

Language

English

Region

England

NLM ID

0266262

PMCID

PMC1395980

Subset

External Links

PubMed source DOI: 10.1113/jphysiol.1966.sp008080 PMC Full Text View journal details

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