Formylmethionine codon AUG as an initiator of polypeptide synthesis.

Science (New York, N.Y.) ·Vol. 153 ·No. 3734 ·1966-07-22 ·Pages 416-8

Thach RE, Dewey KF, Brown JC, Doty P

Abstract

Oligonucleotide messengers containing the sequence AUG at or near the 5' end of the chain stimulate the incorporation of N-formylmethionine,but not of free (unformylated) methionine. AUG is considerably more active in this regard than UUG, the other N-formylmethionine codon. The coding activity of subsequent in-phase triplets in the 3' direction from AUG is markedly stimulated by this codon.

MeSH Terms

Carbon Isotopes Chemical Phenomena Chemistry Escherichia coli Formates Genetic Code Hydrogen-Ion Concentration In Vitro Techniques Methionine Nucleotides Peptides Phenylalanine Radiometry Tritium

Chemicals

Carbon Isotopes Formates Nucleotides Peptides Tritium Phenylalanine Methionine

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Thach R E

Dewey K F

Brown J C

Doty P

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.153.3734.416

Published

1966-07-22

Pages

416-8

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.153.3734.416 View journal details

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Formylmethionine codon AUG as an initiator of polypeptide synthesis.

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