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PMID: 5315912 Published · ppublish English Journal Article

Aspirin and alcohol in gastrointestinal haemorrhage.

Gut ·Vol. 12 ·No. 10 ·1971-10-00 ·Pages 819-21

Needham CD, Kyle J, Jones PF, Johnston SJ, Kerridge DF

Abstract

The intake of aspirin, of alcohol, and of a combination of both, among 817 patients admitted for gastrointestinal haemorrhage is reported. The incidence of ingestion in six diagnostic groups is compared with that in two control groups. Analysis confirms that there is a markedly significant association between overt haemorrhage and the ingestion of aspirin, but this was not shown for alcohol taken alone: the combination of aspirin and alcohol showed a highly significant synergistic effect.

MeSH Terms
Aspirin/adverse effects Drug Synergism Duodenal Ulcer Esophageal and Gastric Varices Ethanol/adverse effects Female Gastritis Gastrointestinal Hemorrhage/chemically induced Hernia, Diaphragmatic Humans Male Peptic Ulcer Hemorrhage/chemically induced Stomach Ulcer Varicose Veins
Chemicals
Ethanol Aspirin
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Needham C D
Kyle J
Jones P F
Johnston S J
Kerridge D F
References (6)
6 references, click to expand
  1. Aspirin and gastric haemorrhage.
    Lancet. 1959 Mar 14;1(7072):539-41 PMID: 13642802
  2. Alcohol, aspirin, and gastrointestinal bleeding.
    Br Med J. 1968 Dec 14;4(5632):664-5 PMID: 5303551
  3. Gastrointestinal haemorrhage and salicylates.
    Lancet. 1958 Nov 1;2(7053):920-5 PMID: 13589048
  4. Epidemiological evidence for the association of aspirin and acute gastrointestinal bleeding.
    Gut. 1970 Jul;11(7):627-34 PMID: 4916213
  5. The influence of some of the salicyl compounds (and alcoholic beverages) on the natural history of peptic ulcer.
    Gastroenterology. 1956 Aug;31(2):198-203 PMID: 13356996
  6. Relationship between aspirin taking and gastroduodenal haemorrhage.
    Gut. 1967 Jun;8(3):301-7 PMID: 5298015
Article Info
Journal
Gut
Abbr.
Gut
ISSN
0017-5749
Published
1971-10-00
Pages
819-21
Language
English
Region
England
NLM ID
2985108R
PMCID
PMC1411878
Subset
IM
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