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PMID: 5305241 Published · ppublish English Journal Article

The X-Y-Z scheme of immunocyte maturation. VII. Cell division and the establishment of short-term IgM memory.

The Journal of experimental medicine ·Vol. 129 ·No. 5 ·1969-05-01 ·Pages 897-907

Byfield P, Sercarz E

Abstract

Short-term IgM memory is established within 1 day after primary injection. This 1 day priming is independent of cell division as it can take place in the pressence of methotrexate or hydroxyurea. The primary response involves a similar 1 day nonproliferative phase. On the contrary, cells responding to a second injection of antigen after short priming intervals begin to proliferate within hours. This implies a qualitative difference between the antigen-sensitive cells in primed and normal animals. After 1 day, further proliferative expansion of memory can occur, which is probably antigen dependent. The response to several dose regimens indicates that repeated antigenic contact is needed to maintain the IgM response.

MeSH Terms
Animals Antigen-Antibody Reactions Antigens Cell Division/drug effects Erythrocytes Female Hemolysis Hydroxyurea/pharmacology Immune Tolerance Immunoglobulin M Injections, Intraperitoneal Leucovorin/pharmacology Male Methods Methotrexate/pharmacology Mice Spleen/immunology Time Factors
Chemicals
Antigens Immunoglobulin M Leucovorin Hydroxyurea Methotrexate
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Byfield P
Sercarz E
References (29)
29 references, click to expand
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.129.5.897
Published
1969-05-01
Pages
897-907
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2138634
Subset
IM
External Links
PubMed source DOI: 10.1084/jem.129.5.897 PMC Full Text View journal details
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