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PMID: 5289717 Published · ppublish English Journal Article

An M-associated protein antigen (MAP) of group A streptococci.

The Journal of hygiene ·Vol. 69 ·No. 4 ·1971-12-00 ·Pages 553-64

Widdowson JP, Maxted WR, Pinney AM

Abstract

A streptococcal antigen that is closely associated with the M-antigen, but is not type specific can be detected by means of a complement-fixation test in extracts of M-positive, but not of M-negative, variants of group A streptococci. Purification of acid extracts results in a concomitant increase in the purity both of the type-specific M-antigen and of the M-associated protein (MAP). Antibody to MAP is present in the sera of patients who have had streptococcal infection. The highest titres are found in patients with rheumatic fever.

MeSH Terms
Antigens/analysis,isolation & purification Antigens, Bacterial/analysis Complement Fixation Tests Humans Peptide Hydrolases/pharmacology Rheumatic Fever/immunology Streptococcal Infections/immunology Streptococcus/immunology
Chemicals
Antigens Antigens, Bacterial Peptide Hydrolases
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Widdowson J P
Maxted W R
Pinney A M
References (22)
22 references, click to expand
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Article Info
Journal
The Journal of hygiene
Abbr.
J Hyg (Lond)
ISSN
0022-1724
DOI
10.1017/s0022172400021823
Published
1971-12-00
Pages
553-64
Language
English
Region
England
NLM ID
0375374
PMCID
PMC2131032
Subset
IM
External Links
PubMed source DOI: 10.1017/s0022172400021823 PMC Full Text View journal details
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