Membrane-associated DNA in the cytoplasm of diploid human lymphocytes.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 68 ·No. 6 ·1971-06-00 ·Pages 1212-6

Lerner RA, Meinke W, Goldstein DA

Abstract

A species of DNA that is apparently associated with the plasma membrane of diploid human lymphocytes that are continously growing is described. This DNA differes from nuclear or mitochondrial DNA by virtue of its location in the cell, time of synthesis in the cell cycle, and various physical properties. At present, the role of this DNA is unknown.

MeSH Terms

Antigen-Antibody Reactions Autoradiography Bile Acids and Salts/pharmacology Binding Sites Carbon Isotopes Cell Fractionation Cell Membrane/analysis,immunology Cells, Cultured Centrifugation, Density Gradient Cytoplasm/analysis DNA/analysis,biosynthesis Deoxyribonucleases/pharmacology Diploidy Humans Immunoglobulin G/analysis Iodine Isotopes Lymphocytes/analysis Microscopy, Electron Pronase/pharmacology Ribonucleases/pharmacology Thymidine/metabolism Tritium

Chemicals

Bile Acids and Salts Carbon Isotopes Immunoglobulin G Iodine Isotopes Tritium DNA Deoxyribonucleases Ribonucleases Pronase Thymidine

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Lerner R A

Meinke W

Goldstein D A

References (21)

21 references, click to expand

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Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.68.6.1212

Published

1971-06-00

Pages

1212-6

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC389156

Subset

External Links

PubMed source DOI: 10.1073/pnas.68.6.1212 PMC Full Text View journal details

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Membrane-associated DNA in the cytoplasm of diploid human lymphocytes.

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