Assignment of four linkage groups to chromosomes in Mus musculus and a cytogenetic method for locating their centromeric ends.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 68 ·No. 11 ·1971-11-00 ·Pages 2699-702

Miller DA, Kouri RE, Dev VG, Grewal MS, Hutton JJ, Miller OJ

Abstract

The mitotic chromosomes in primary cultured cells from mouse embryos of the translocation stocks, T(5;18)26H, T(5;11)7Ca, and T(14;17)264Ca, have been identified by their distinctive fluorescent-banding patterns after staining with quinacrine mustard. In this way, linkage group (LG) V has been assigned to chromosome 2, LGXVIII to chromosome 9, and LGXIV and LGXVII to either of chromosomes 3 or 13. The assignment of LGXI to chromosome 6 has been confirmed. The centromeres of chromosomes 1 (LGXIII), 2 (LGV), 9 (LGXVIII), and 16 (LGIX) have been located at the ends nearest the genes fuzzy (fz), Danforth's short tail (Sd), nervous (nr), and T of their respective linkage groups by a cytogenetic method. The centromere of the X (LGXX) has been tentatively assigned to the end nearest to the scurfy (sf) locus.

MeSH Terms

Animals Cells, Cultured Chromosomes/analysis Cytogenetics Embryo, Mammalian Female Genetic Linkage Karyotyping Male Mice Mice, Inbred Strains Mitosis

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

Miller D A

Kouri R E

Dev V G

Grewal M S

Hutton J J

Miller O J

References (8)

8 references, click to expand

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Chemical differentiation along metaphase chromosomes.
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Differential transmission of translocations induced in spermatogonia of mice by irradiation.
Cytogenetics. 1969;8(6):447-70 PMID: 5365250
Identification of acrocentric chromosomes involved in the formation of "fusion"-metacentrics in mice. Proposal for nomenclature of M. poschiavinus metacentrics.
Experientia. 1970 Sep 26;26(9):1018-9 PMID: 5478611
Producing and detecting paracentric chromosomal inversions in mice.
Mutat Res. 1971 Jan;11(1):59-69 PMID: 5556351
Identification of the mouse karyotype by quinacrine fluorescence, and tentative assignment of seven linkage groups.
Proc Natl Acad Sci U S A. 1971 Jul;68(7):1530-3 PMID: 5283942
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Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.68.11.2699

Published

1971-11-00

Pages

2699-702

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC389504

Subset

External Links

PubMed source DOI: 10.1073/pnas.68.11.2699 PMC Full Text View journal details

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Assignment of four linkage groups to chromosomes in Mus musculus and a cytogenetic method for locating their centromeric ends.

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