Home LiteratureArticle Details
PMID: 52849 Published · ppublish English Journal Article

Prostaglandin, slow-reacting substance, and histamine release from anaphylactic guinea-pig hearts, and its pharmacological modification.

Naunyn-Schmiedeberg's archives of pharmacology ·Vol. 289 ·No. 1 ·1975-00-00 ·Pages 65-76

Liebig R, Bernauer W, Peskar BA

Abstract

Prostaglandins (Pgs), slow-reacting substance of anaphylaxis (SRS-A), and histamine were released from anaphylactic isolated perfused guinea pig hearts. Pgs were to the greatest part of the F2alpha-type. PgE2 was found in traces only. Neither PgA2, nor the metabolites 13,14-dihydro-15-keto-PgF2alpha and 13,14-dihydro-15-keto-PgE2 were detected in the perfusates. Isoproterenol reduced the PgF2alpha output significantly. This effect was increased by the addition of theophylline. Propranolol did not reverse the effect of isoproterenol, but in a high concentration (5 mug/ml) reduced the PgF2alpha output for its own. Indomethacin completely abolished the anaphylactic prostaglandin release. The histamine liberation was significantly decreased only by the combination of isoproterenol and theophylline, and also by a high concentration of propranolol (5 mug/ml). In contrast to the Pg release, the anaphylactic SRS-A and histamine liberation was not abolished by indomethacin, but rather increased. The results are discussed in view of the possible role of the released substances in the functional events of cardiac anaphylaxis.

MeSH Terms
Anaphylaxis/metabolism Animals Coronary Circulation/drug effects Female Guinea Pigs Heart Rate/drug effects Histamine Release/drug effects In Vitro Techniques Isoproterenol/pharmacology Male Myocardial Contraction/drug effects Myocardium/metabolism Papillary Muscles/metabolism Propranolol/pharmacology Prostaglandins/metabolism Prostaglandins A/metabolism Prostaglandins E/metabolism Prostaglandins F/metabolism SRS-A/metabolism Theophylline/pharmacology
Chemicals
Prostaglandins Prostaglandins A Prostaglandins E Prostaglandins F SRS-A Propranolol Theophylline Isoproterenol
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Liebig R
Bernauer W
Peskar B A
References (36)
36 references, click to expand
  1. The occurrence of a lipid-soluble smooth-muscle stimulating principle ('SRS') in anaphylactic reaction.
    Acta Physiol Scand. 1960 Mar 18;48:167-77 PMID: 13809019
  2. The mechanism of histamine release in anaphylactic reaction in guinea pig and rat.
    Acta Physiol Scand. 1960 Mar 18;48:146-66 PMID: 13809018
  3. Effects of prostaglandins E1, A1 and F2a on the coronary and peripheral circulations.
    Proc Soc Exp Biol Med. 1968 Apr;127(4):1160-3 PMID: 5655659
  4. The release of histamine and formation of a slow-reacting substance (SRS-A) during anaphylactic shock.
    J Physiol. 1960 Jun;151:416-35 PMID: 13804592
  5. Late Deaths occurring in Active Anaphylaxis.
    J Hyg (Lond). 1936 Oct;36(4):588-93 PMID: 20475356
  6. ANAPHYLAXIS IN THE ISOLATED HEART.
    J Exp Med. 1938 Jan 31;67(2):169-80 PMID: 19870713
  7. Prostaglandin E 1 and cardiac arrhythmia.
    Eur J Pharmacol. 1972 May;18(3):392-5 PMID: 5035626
  8. A comparison of the effects of anaphylactic shock and of chemical histamine releasers.
    J Physiol. 1952 Dec;118(4):461-78 PMID: 13023644
  9. Acute and protracted anaphylactic shock in guinea pigs after subcutaneous eliciting injection of antigen.
    J Immunol. 1959 Feb;82(2):138-45 PMID: 13631242
  10. Influence of prostaglandins on autonomic responses.
    Am J Physiol. 1971 Nov;221(5):1470-5 PMID: 4330893
  11. Effects of prostaglandins on experimental arrhythmias.
    Pol J Pharmacol Pharm. 1974 Jan-Apr;26(1):151-8 PMID: 4838275
  12. Release of prostaglandins from isolated cat spleen by angiotensin and vasopressin.
    Naunyn Schmiedebergs Arch Pharmacol. 1973;279(3):227-34 PMID: 4356205
  13. Direct actions of prostaglandins E1, A1, F2 on myocardial contraction.
    Prostaglandins. 1973 Mar;3(3):323-36 PMID: 4729576
  14. THE SPECIES SPECIFICITY OF PROSTAGLANDIN E 1 EFFECTS ON ISOLATED HEART.
    Med Pharmacol Exp Int J Exp Med. 1965;13:233-40 PMID: 14332759
  15. On the specificity of antisera against prostaglandins A2 and E2.
    FEBS Lett. 1973 Dec 1;37(2):192-6 PMID: 4202823
  16. [ANAPHYLACTIC REACTIONS OF PERFUSED HEART PREPARATIONS, ISOLATED ATRIAL PREPARATIONS AND ISOLATED PAPILLARY MUSCLES].
    Arch Int Pharmacodyn Ther. 1964 May 1;149:136-52 PMID: 14169877
  17. Histamine in the pigs: determination, distribution, release and pharmacological actions.
    Eur J Pharmacol. 1971 Apr;14(2):155-75 PMID: 4133191
  18. Release of prostaglandins, a prostaglandin metabolite, slow-reacting substance and histamine from anaphylactic lungs, and its modification by catecholamines.
    Naunyn Schmiedebergs Arch Pharmacol. 1974;284(3):279-93 PMID: 4139670
  19. Histamine release in anaphylactic shock from various tissues of the guinea-pig.
    J Physiol. 1939 Apr 14;95(3):393-403 PMID: 16995097
  20. Hypoxia causes prostaglandin release from perfused rabbit hearts.
    Acta Physiol Scand. 1974 May;91(1):133-5 PMID: 4835718
  21. [Comparative studies on anaphylactic shock and anaphylatoxin shock on the intact guinea pig].
    Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1961;242:65-75 PMID: 13705169
  22. Studies on heart anaphylaxis. V. Cross-desensitisation between antigen, anaphylatoxin, and compound 48-80 in the guinea-pig papillary muscle.
    Int Arch Allergy Appl Immunol. 1972;42(1):136-51 PMID: 5060266
  23. Effects of exogenous and immunologically released histamine on the isolated heart: a quantitative comparison.
    J Pharmacol Exp Ther. 1972 Aug;182(2):227-38 PMID: 4114900
  24. Prostaglandin release by the isolated perfused rabbit heart.
    Prostaglandins. 1973 Apr;3(4):439-45 PMID: 4354088
  25. THE EFFECTS OF ANAPHYLAXIS, AND OF HISTAMINE, UPON THE CORONARY ARTERIES IN THE ISOLATED HEART.
    J Exp Med. 1939 Mar 31;69(4):546-53 PMID: 19870863
  26. Immunological release of histamine and slow-reacting substance of anaphylaxis from human lung : I. Modulation by agents influencing cellular levels of cyclic 3',5'-adenosine monophosphate.
    J Exp Med. 1971 Sep 1;134(3):136-48 PMID: 19867362
  27. Modification of basal release of prostaglandins from rabbit isolated hearts.
    Prostaglandins. 1974 Sep 25;7(6):473-86 PMID: 4414700
  28. The influences of andrenotropic drugs and noradrenaline on the histamine release in cardiac anaphylaxis in vitro.
    J Physiol. 1966 Jun;184(4):924-41 PMID: 4380397
  29. Selective inhibitor of slow reacting substance of anaphylaxis.
    Nat New Biol. 1973 Oct 17;245(146):215-7 PMID: 4147765
  30. Studies on heart anaphylaxis. I. Effect of antigen and histamine on the guinea pig heart-lung preparation.
    Int Arch Allergy Appl Immunol. 1969;35(5):476-94 PMID: 4388689
  31. Evidence for the presence of a prostaglandin E 2 -9-keto reductase in rat organs.
    Biochem Biophys Res Commun. 1973 Jun 8;52(3):717-24 PMID: 4736322
  32. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs.
    Nat New Biol. 1971 Jun 23;231(25):232-5 PMID: 5284360
  33. A method for the fluorometric assay of histamine in tissues.
    J Pharmacol Exp Ther. 1959 Nov;127:182-6 PMID: 14446178
  34. Antisera against 13,14-dihydro-15-keto-prostaglandin E2.
    FEBS Lett. 1974 Jul 1;43(1):45-8 PMID: 4859213
  35. Histamine release and intracellular potentials during anaphylaxis in the isolated heart.
    Circ Res. 1960 Jul;8:713-23 PMID: 13821916
  36. Studies on heart anaphylaxis. 3. Effect of antigen and histamine on perfused guinea-pig heart.
    Arch Int Pharmacodyn Ther. 1970 Mar;184(1):129-57 PMID: 4393630
Article Info
Journal
Naunyn-Schmiedeberg's archives of pharmacology
Abbr.
Naunyn Schmiedebergs Arch Pharmacol
ISSN
0028-1298
DOI
10.1007/BF00498030
Published
1975-00-00
Pages
65-76
Language
English
Region
Germany
NLM ID
0326264
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00498030 View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2