Chromosomal radiosensitivity of ataxia telangiectasia cells at different cell cycle stages.

Human genetics ·Vol. 52 ·No. 1 ·1979-11-01 ·Pages 127-32

Natarajan AT, Meyers M

Abstract

X-ray induced chromosomal aberrations in peripheral blood lymphocytes as well as in skin fibroblasts from ataxia telangiectasia patients, and from normal individuals were studied. At all stages of cell cycles-namely G0, G1, and G2, more aberrations were induced in AT cells than in normal cells. In addition, AT cells were sensitive to induction of chromosomal aberrations by tritium beta rays from incorporated radioactive thymidine. Possible reasons for the increased sensitivity of AT cells for induction of chromosomal aberrations by ionizing radiations are discussed.

MeSH Terms

Ataxia Telangiectasia/genetics Cell Cycle Cells, Cultured Chromatids/radiation effects Chromosome Aberrations Chromosomes, Human/radiation effects Fibroblasts/radiation effects Humans Lymphocytes/radiation effects Thymidine Tritium X-Rays

Chemicals

Tritium Thymidine

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Natarajan A T

Meyers M

References (12)

12 references, click to expand

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Is chromatid-type damage in ataxia telangiectasia after irradiation at G0 a consequence of defective repair?
Nature. 1976 Apr 1;260(5550):441-3 PMID: 1256587
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Mutat Res. 1978 Jan;49(1):45-54 PMID: 414132
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Nature. 1976 Apr 1;260(5550):444-7 PMID: 1256588
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Nature. 1975 Dec 4;258(5534):427-9 PMID: 1196376
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Article Info

Journal

Human genetics

Abbr.

Hum Genet

ISSN

0340-6717

DOI

10.1007/BF00284606

Published

1979-11-01

Pages

127-32

Language

English

Region

Germany

NLM ID

7613873

Subset

External Links

PubMed source DOI: 10.1007/BF00284606 View journal details

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Chromosomal radiosensitivity of ataxia telangiectasia cells at different cell cycle stages.

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