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PMID: 527868 Published · ppublish English Journal Article

Quantitative study of mucosal structure, enzyme activities and phenylalanine accumulation in jejunal biopsies of patients with early and late onset diabetes.

Gut ·Vol. 20 ·No. 11 ·1979-11-00 ·Pages 1001-7

Riecken EO, Zennek A, Lay A, Menge H

Abstract

A study of the three-dimensional structure of the upper jejunal mucosa in diabetics has been carried out. The structural findings were related to 14C-L-phenylalanine uptake in vitro, sucrase activity in mucosal homogenates, and the enzyme content of the absorptive cells as measured cytophotometrically. A low grade mucosal transformation of the sprue-type was found, which was associated with decreased sucrase activity, and with no reduction in phenylalanine accumulation. On the other hand the specific activities of alkaline phosphatase, non-specific esterase, and succinic dehydrogenase in the surface cells remained unchanged.

MeSH Terms
Adult Aged Biopsy Diabetes Mellitus/enzymology,metabolism,pathology Female Humans Intestinal Mucosa/enzymology,metabolism,pathology Jejunum/enzymology,metabolism,pathology Male Middle Aged Phenylalanine/metabolism Sucrase/metabolism
Chemicals
Phenylalanine Sucrase
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Riecken E O
Zennek A
Lay A
Menge H
References (37)
37 references, click to expand
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Article Info
Journal
Gut
Abbr.
Gut
ISSN
0017-5749
DOI
10.1136/gut.20.11.1001
Published
1979-11-00
Pages
1001-7
Language
English
Region
England
NLM ID
2985108R
PMCID
PMC1412670
Subset
IM
External Links
PubMed source DOI: 10.1136/gut.20.11.1001 PMC Full Text View journal details
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