Enhanced immunogenicity of chemically-coated syngeneic tumor cells.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 68 ·No. 2 ·1971-02-00 ·Pages 469-72

Martin WJ, Wunderlich JR, Fletcher F, Inman JK

Abstract

The immunogenicity of the EL-4 strain of mouse lymphoid leukemia cells in syngeneic C57BL/6 recipients was enhanced by in vitro coating of the cells with either Concanavalin A or dinitrophenylaminocaproate. The tumor-specific immune response was quantitated using a recently developed assay that involves in vitro cell-mediated cytotoxicity.

MeSH Terms

Aminocaproates/pharmacology Animals Antigens Ascites Blood/immunology Cell Line Chromium Isotopes Dinitrophenols/pharmacology

Chemicals

Aminocaproates Antigens Chromium Isotopes Dinitrophenols

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Martin W J

Wunderlich J R

Fletcher F

Inman J K

References (8)

8 references, click to expand

Production of active immunity to malignant neoplastic tissue. Chemical coupling to an antigenic protein carrier.
Cancer. 1966 Jun;19(6):739-49 PMID: 5328244
Some physical and chemical properties of concanavalin A, the phytohemagglutinin of the jack bean.
Biochemistry. 1967 Jan;6(1):105-11 PMID: 6030308
Serotyping for homotransplantation. 18. Refinement of microdroplet lymphocyte cytotoxicity test.
Transplantation. 1968 Nov;6(8):913-27 PMID: 5696820
Ability of CBA mice to produce anti-idiotypic sera to 5563 myeloma protein.
Nature. 1970 Jul 18;227(5255):273-4 PMID: 4193610
Differential toxicity on normal and transformed cells in vitro and inhibition of tumour development in vivo by concanavalin A.
Nature. 1970 Sep 19;227(5264):1244-6 PMID: 4318127
Quantitative in vitro assay of cytotoxic cellular immunity.
J Natl Cancer Inst. 1970 Oct;45(4):761-72 PMID: 5513502
Immunologic approach to cancer.
Transplant Proc. 1970 Mar;2(1):92-103 PMID: 4107297
Passive immunity in mice against C57BL leukosis E.L. 4 by means of iso-immune serum.
Cancer Res. 1956 May;16(4):338-43 PMID: 13316761

Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.68.2.469

Published

1971-02-00

Pages

469-72

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC388962

Subset

External Links

PubMed source DOI: 10.1073/pnas.68.2.469 PMC Full Text View journal details

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Enhanced immunogenicity of chemically-coated syngeneic tumor cells.

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