Transformation of rat and hamster embryo cells by extracts of city smog.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 68 ·No. 2 ·1971-02-00 ·Pages 445-9

Freeman AE, Price PJ, Bryan RJ, Gordon RJ, Gilden RV, Kelloff GJ, Huebner RJ

Abstract

Extracts of particulate matter from condensates of city air were tested for their ability to transform rat or hamster cell cultures. Uninfected rat embryo cultures were not transformed, but cultures chronically infected with Rauscher leukemia virus were transformed by benzpyrene or by extracts of city smog. The smog extracts were 600 times more active than pure benzpyrene as transforming agents. Hamster embryo cultures infected with hamster leukemia virus were equally as sensitive as leukemia-infected rat cultures to the transforming effects of smog; uninfected hamster cultures were also transformed, although tenfold higher doses of smog extract were required.

MeSH Terms

Air Pollution Benzopyrenes/pharmacology Cell Line Cell Transformation, Neoplastic/drug effects,embryology

Chemicals

Benzopyrenes

Authors & Affiliations

7 authors, click to expand affiliations / ORCID

Freeman A E

Price P J

Bryan R J

Gordon R J

Gilden R V

Kelloff G J

Huebner R J

References (13)

13 references, click to expand

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Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.68.2.445

Published

1971-02-00

Pages

445-9

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC388957

Subset

External Links

PubMed source DOI: 10.1073/pnas.68.2.445 PMC Full Text View journal details

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Transformation of rat and hamster embryo cells by extracts of city smog.

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