A genetic marker in the variable region of light chains of mouse immunoglobulins.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 67 ·No. 3 ·1970-11-00 ·Pages 1192-9

Edelman GM, Gottlieb PD

Abstract

A genetic variation was observed upon autoradiographic comparison of tryptic peptide maps of (14)C-labeled normal light chains from 17 different inbred strains of mice. The difference was found in strains AKR/J, C58/J, and RF/J. Chemical analyses showed that the differences were in a region of the amino acid sequence in the neighborhood of half-cystine I of the variable region of the light chain. Breeding experiments showed that the difference segregated in a classical Mendelian fashion.

MeSH Terms

Amino Acids/analysis Animals Autoradiography Carbon Isotopes Centrifugation, Density Gradient Electrophoresis Genetic Variation Immunochemistry Immunogenetics Immunoglobulin G Immunoglobulins Inbreeding Mice Peptides/analysis

Chemicals

Amino Acids Carbon Isotopes Immunoglobulin G Immunoglobulins Peptides

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Edelman G M

Gottlieb P D

References (16)

16 references, click to expand

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Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.67.3.1192

Published

1970-11-00

Pages

1192-9

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC283336

Subset

External Links

PubMed source DOI: 10.1073/pnas.67.3.1192 PMC Full Text View journal details

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A genetic marker in the variable region of light chains of mouse immunoglobulins.

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