On the geometrical arrangement of the protein subunits of human serum low-density lipoprotein: evidence for a dodecahedral model.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 64 ·No. 1 ·1969-09-00 ·Pages 304-10

Pollard H, Scanu AM, Taylor EW

Abstract

Ultracentrifugal and electron microscopic studies of human serum low-density lipoprotein (LDL) and several of its derivatives led to the formulation of a model in which the 20 protein subunits, probably globular, are arranged in a dodecahedral pattern with icosahedral symmetry. In such a model the LDL surface is occupied by both protein and lipids, predominantly phospholipids, as supported by the results of the hydrolysis of LDL by phospholipase A and C. Neutral lipids (cholesterol esters and glycerides) would be in the interior of the molecule.

MeSH Terms

Adult Humans Lipoproteins/blood Male Microscopy, Electron Models, Chemical Molecular Weight Surface Properties Ultracentrifugation

Chemicals

Lipoproteins

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Pollard H

Scanu A M

Taylor E W

References (13)

13 references, click to expand

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Isopiestic compositions as a measure of preferential interactions of macromolecules in two-component solvents. Application to proteins in concentrated aqueous cesium chloride and guanidine hydrochloride.
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J Lipid Res. 1968 Nov;9(6):789-93 PMID: 5685271
On the conformational instability of human serum low-density lipoprotein: effect of temperature.
Proc Natl Acad Sci U S A. 1969 Jan;62(1):171-8 PMID: 5253654
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The structural relationship between ferritin protein and its mineral core.
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The origin, metabolism, and structure of normal human serum lipoproteins.
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Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.64.1.304

Published

1969-09-00

Pages

304-10

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC286162

Subset

External Links

PubMed source DOI: 10.1073/pnas.64.1.304 PMC Full Text View journal details

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On the geometrical arrangement of the protein subunits of human serum low-density lipoprotein: evidence for a dodecahedral model.

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