Home LiteratureArticle Details
PMID: 5261030 Published · ppublish English Journal Article

Preliminary analysis of the requirements for fusion from within and fusion from without by Newcastle disease virus.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 64 ·No. 2 ·1969-10-00 ·Pages 536-43

Bratt MA, Gallaher WR

Abstract

Different strains of Newcastle disease virus vary in their ability to induce cell fusion. When administered to cells at high multiplicities of infection some strains induce cell fusion within three hours. This type of fusion is apparently caused by the virus particles in the inoculum, since it can be induced by noninfectious virus and does not require protein synthesis for induction. It has been designated fusion from without (FFWO). Other strains induce fusion mainly at low multiplicities of infection. This fusion is induced only by infectious virus, and requires protein synthesis for induction. Probably included among these required proteins is a viral antigen which must be available at the cell surface in order for fusion to occur. This type of fusion has been designated fusion from within (FFWI).

MeSH Terms
Adhesiveness Animals Chick Embryo Cytopathogenic Effect, Viral Newcastle disease virus Surface Properties Virus Cultivation
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Bratt M A
Gallaher W R
References (20)
20 references, click to expand
  1. Polykaryocytosis.
    Cold Spring Harb Symp Quant Biol. 1962;27:327-42 PMID: 13982495
  2. Newcastle disease virus complementary RNA: its relationship to the viral genome and its accumulation in the presence or absence of actinomycin D.
    Virology. 1967 Oct;33(2):227-33 PMID: 6053140
  3. Analysis of giant polynuclear cell formation caused by HVJ virus from Ehrlich's ascites tumor cells. I. Microscopic observation of giant polynuclear cell formation.
    Exp Cell Res. 1962 Feb;26:98-107 PMID: 14481504
  4. Analysis of giant polynuclear cell formation caused by HVJ virus from Ehrlich's ascites tumor cells. II. Quantitative analysis of giant polynuclear cell formation.
    Exp Cell Res. 1962 Feb;26:108-18 PMID: 14481502
  5. Participation of deoxyribonucleic acid in the multiplication of influenza virus.
    Nature. 1962 Jun 23;194:1139-40 PMID: 13865326
  6. RNA synthesis in NDV-infected chick embryo cells treated with different concentrations of actinomycin D.
    Virology. 1969 Sep;39(1):141-5 PMID: 5818112
  7. Studies on the transfer of subviral infectivity from SV40-induced hamster tumor cells to indicator cells.
    Virology. 1966 Apr;28(4):501-9 PMID: 4287200
  8. Replication of poliovirus I in chick embryo and hamster cells exposed to sendai virus.
    Proc Natl Acad Sci U S A. 1967 Mar;57(3):637-44 PMID: 16591511
  9. On the role of the response of the cell membrane in determining virus virulence. Contrasting effects of the parainfluenza virus SV5 in two cell types.
    J Exp Med. 1966 Sep 1;124(3):501-20 PMID: 4288512
  10. Fatty acid composition of three strains of Newcastle disease virus.
    Virology. 1969 Mar;37(3):492-4 PMID: 5777567
  11. Specific interference among strains of Newcastle disease virus. 3. Mechanisms of interference.
    Virology. 1968 Jul;35(3):395-407 PMID: 5662869
  12. Cell fusion by various strains of Newcastle disease virus and their virulence.
    J Virol. 1969 May;3(5):539-40 PMID: 5786185
  13. Analysis of giant polynuclear cell formation caused by HVJ virus from Ehrlich's ascites tumor cells. III. Relationship between cell condition and fusion reaction or cell degeneration reaction.
    Exp Cell Res. 1962 Feb;26:119-28 PMID: 14481503
  14. MEASLES VIRUS GIANT CELL INDUCING FACTOR (FUSION FACTOR).
    Virology. 1965 Jun;26:311-25 PMID: 14323997
  15. Use of actinomycin D to unmask RNA synthesis induced by Newcastle disease virus.
    Biochem Biophys Res Commun. 1962 Sep 25;9:156-61 PMID: 14032882
  16. POLYKARYOCYTOSIS INDUCED BY NEWCASTLE DISEASE VIRUS IN MONOLAYERS OF ANIMAL CELLS.
    Virology. 1965 Jun;26:228-45 PMID: 14323991
  17. HYBRID CELLS DERIVED FROM MOUSE AND MAN: ARTIFICIAL HETEROKARYONS OF MAMMALIAN CELLS FROM DIFFERENT SPECIES.
    Nature. 1965 Feb 13;205:640-6 PMID: 14287398
  18. Inclusion bodies from Newcastle disease virus in HeLa cells.
    J Bacteriol. 1961 Jul;82:151-2 PMID: 13719843
  19. Studies on the inactivation of cell-fusing property of Newcastle disease virus by phospholipase A.
    Virology. 1967 Feb;31(2):385-8 PMID: 6021100
  20. CYTOLOGICAL STUDIES OF NEWCASTLE DISEASE VIRUS (NDV) IN HEP-2 CELLS.
    Proc Soc Exp Biol Med. 1964 Feb;115:281-6 PMID: 14121589
Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.64.2.536
Published
1969-10-00
Pages
536-43
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC223377
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.64.2.536 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2