Mechanism of proflavin mutagenesis.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 63 ·No. 4 ·1969-08-00 ·Pages 1196-7

Sarabhai A, Lamfrom H

Abstract

The mutagenic action of proflavin on bacteriophage T4 is greater in the presence of defective T4 ligase than in the presence of normal T4 ligase. This suggests that the persistence of single-strand breaks in DNA enhances proflavin mutagenesis.

MeSH Terms

Coliphages/drug effects DNA, Viral/pharmacology Flavins/pharmacology Mutagens/pharmacology

Chemicals

DNA, Viral Flavins Mutagens

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Sarabhai A

Lamfrom H

References (5)

5 references, click to expand

The structure of the DNA-acridine complex.
Proc Natl Acad Sci U S A. 1963 Jan 15;49:94-102 PMID: 13929834
A frame-shift mutation involving the addition of two base pairs in the lysozyme gene of phage t4.
Proc Natl Acad Sci U S A. 1966 Dec;56(6):1692-8 PMID: 16591406
Enzymatic breakage and joining of deoxyribonucleic acid. II. The structural gene for polynucleotide ligase in bacteriophage T4.
Proc Natl Acad Sci U S A. 1967 Aug;58(2):665-72 PMID: 5234326
Change of a sequence of amino acids in phage T4 lysozyme by acridine-induced mutations.
Proc Natl Acad Sci U S A. 1966 Aug;56(2):500-7 PMID: 5229972
General nature of the genetic code for proteins.
Nature. 1961 Dec 30;192:1227-32 PMID: 13882203

Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.63.4.1196

Published

1969-08-00

Pages

1196-7

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC223449

Subset

External Links

PubMed source DOI: 10.1073/pnas.63.4.1196 PMC Full Text View journal details

Analysis Services

Mechanism of proflavin mutagenesis.

Contact

WeChat Official Account