Studies on the control of pyrimidine biosynthesis in human diploid cell strains. II. Effects of 5-azaorotic acid, barbituric acid, and pyrimidine precursors on cellular phenotype.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 57 ·No. 5 ·1967-05-00 ·Pages 1267-74

Pinsky L, Krooth RS

Abstract

暂无摘要

MeSH Terms

Barbiturates/pharmacology Carboxy-Lyases/metabolism Culture Techniques Enzymes/pharmacology Glucosyltransferases/metabolism Humans Molecular Biology Mutation Nucleosides/pharmacology Orotic Acid/pharmacology Triazines/pharmacology Uracil Nucleotides/biosynthesis

Chemicals

Barbiturates Enzymes Nucleosides Triazines Uracil Nucleotides Orotic Acid Glucosyltransferases Carboxy-Lyases

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Pinsky L

Krooth R S

References (13)

13 references, click to expand

Refractory megaloblastic anemia associated with excretion of orotic acid.
Blood. 1959 Jun;14(6):615-34 PMID: 13651334
Orotidylic acid decarboxylase: inhibition studies with azauridine 5'-phosphate.
J Biol Chem. 1960 Oct;235:2917-9 PMID: 13711194
Regulatory control of pyrimidine biosynthesis in mammalian systems.
Adv Enzyme Regul. 1964;2:213-36 PMID: 5863089
Pyrimidine metabolism in man. V. The measurement in vivo of the biochemical effect of antineoplastic agents in animal and human subjects.
J Clin Invest. 1962 Apr;41:871-83 PMID: 14489640
STUDIES ON DIHYDROOROTASE ACTIVITY IN PREPARATIONS FROM NOVIKOFF ASCITES HEPATOMA CELLS.
Arch Biochem Biophys. 1964 Mar;104:381-6 PMID: 14161005
PROPERTIES ODF DIPLOID CELL STRAINS DEVELOPED FROM PATIENTS WITH AN INHERITED ABNORMALITY OF URIDINE BIOSYNTHESIS.
Cold Spring Harb Symp Quant Biol. 1964;29:189-212 PMID: 14278466
Control of pyrimidine biosynthesis in Escherichia coli by a feed-back mechanism.
J Biol Chem. 1956 Aug;221(2):757-70 PMID: 13357469
Coordination of the synthesis of the enzymes in the pyrimidine pathway of E. coli.
J Mol Biol. 1962 Dec;5:618-34 PMID: 13970180
PYRIMIDINE METABOLISM IN MAN. IV. THE ENZYMATIC DEFECT OF OROTIC ACIDURIA.
J Clin Invest. 1961 Apr;40(4):656-64 PMID: 16695858
Purification and properties of dihydro-orotic dehydrogenase.
J Biol Chem. 1958 Dec;233(6):1398-406 PMID: 13610849
AN ANALYSIS OF THE LACK OF DRUG SYNERGISM DURING SEQUENTIAL BLOCKADE OF DE NOVO PYRIMIDINE BIOSYNTHESIS.
Cancer Res. 1964 Jul;24:1002-7 PMID: 14195336
The biochemical activity of 6-azauridine: interference with pyrimidine metabolism in transplantable mouse tumors.
J Biol Chem. 1959 Nov;234:2992-7 PMID: 14430761
The regulation of synthesis of leucine biosynthetic enzymes in Neurospora.
Proc Natl Acad Sci U S A. 1965 Dec;54(6):1538-46 PMID: 5218909

Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.57.5.1267

Published

1967-05-00

Pages

1267-74

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC224467

Subset

External Links

PubMed source DOI: 10.1073/pnas.57.5.1267 PMC Full Text View journal details

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Studies on the control of pyrimidine biosynthesis in human diploid cell strains. II. Effects of 5-azaorotic acid, barbituric acid, and pyrimidine precursors on cellular phenotype.

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