The conversion of serine at the active site of subtilisin to cysteine: a "chemical mutation".

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 56 ·No. 5 ·1966-11-00 ·Pages 1606-11

Neet KE, Koshland DE

Abstract

暂无摘要

MeSH Terms

Chemical Phenomena Chemistry Cysteine Endopeptidases Mutation Serine

Chemicals

Serine Endopeptidases Cysteine

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Neet K E

Koshland D E

References (13)

13 references, click to expand

The effect of substituents on the deacylation of benzoyl-chymotrypsins.
Biochemistry. 1962 Sep;1:883-93 PMID: 14018421
STUDIES ON THE MECHANISM AND ACTIVE SITE FOR THE ESTEROLYTIC ACTIVITY OF 3-PHOSPHOGLYCERALDEHYDE DEHYDROGENASE.
J Biol Chem. 1964 Jul;239:2316-27 PMID: 14209963
Cytochrome c.
Adv Protein Chem. 1966;21:113-286 PMID: 5333288
A KINETIC STUDY OF THE REACTION OF THIOLS WITH P-NITROPHENYL ACETATE.
Biochemistry. 1964 Jun;3:754-8 PMID: 14211610
ROLE OF SERINE IN CHYMOTRYPSIN ACTION. CONVERSION OF THE ACTIVE SERINE TO DEHYDROALANINE.
Proc Natl Acad Sci U S A. 1963 Nov;50:931-5 PMID: 14082360
Imidazole catalysis. III. General base catalysis and the reactions of acetyl imidazole with thiols and amines.
J Biol Chem. 1959 May;234(5):1280-5 PMID: 13654362
A change in specificity of chymotrypsin caused by chemical modification of methionine residues.
J Biol Chem. 1966 Jun 10;241(11):2687-93 PMID: 5911641
A comparison of two proteinases from Bacillus subtilis.
C R Trav Lab Carlsberg. 1960;32:63-74 PMID: 13731648
Amino-acid sequence about the reactive serine of a proteolytic enzyme from Bacillus subtilis.
Nature. 1960 Sep 3;187:872-3 PMID: 14441480
The formation of anhydrochymotrypsin by removing the elements of water from the serine at the active site.
J Am Chem Soc. 1966 Aug 20;88(16):3851-9 PMID: 5916376
The alpha-chymotryptic ydrolysis of glycine esters.
Biochem J. 1966 May;99(2):275-82 PMID: 5944238
The reaction of carbanions with N,S-diacetylcysteamine. A model for enzymatic carbon--carbon condensation.
J Am Chem Soc. 1965 Sep 5;87(17):3863-74 PMID: 5845265
Properties and conformation of the histidine residues at the active site of ribonuclease.
J Biol Chem. 1963 Jul;238:2421-8 PMID: 14023812

Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.56.5.1606

Published

1966-11-00

Pages

1606-11

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC220044

Subset

External Links

PubMed source DOI: 10.1073/pnas.56.5.1606 PMC Full Text View journal details

Analysis Services

The conversion of serine at the active site of subtilisin to cysteine: a "chemical mutation".

Contact

WeChat Official Account