4,4'-Dihydroxyphenazone as an urinary metabolite of phenazone in different species including man.

Naunyn-Schmiedeberg's archives of pharmacology ·Vol. 309 ·No. 2 ·1979-11-00 ·Pages 203-5

Bässmann H, Böttcher J, Schüppel R

Abstract

4,4'-Dihydroxyphenazone (4-hydroxy-1-4'-hydroxyphenyl)-2,3-dimethyl-3-pyrazoline-5-one) was isolated as a metabolite of phenazone (antipyrine) after acid hydrolysis of rat urine. This was characterized and identified by NMR, MS, IR, UV, Fp and epsilon270. After dosage with phenazone, 4,4'-dihydroxyphenazone is excreted in conjugated form by man, rabbit, guinea pig and rat. In the rat it is further shown, that conjugates of 4,4'-dihydroxyphenazone are formed by glucuronidation as well as by sulfatation. The metabolite seems to add substantially to the overall metabolic pattern of phenazone in these species.

MeSH Terms

Animals Antipyrine/metabolism,urine Guinea Pigs Humans Hydroxylation Male Rabbits Rats Species Specificity

Chemicals

Antipyrine

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Bässmann H

Böttcher J

Schüppel R

References (11)

11 references, click to expand

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Article Info

Journal

Naunyn-Schmiedeberg's archives of pharmacology

Abbr.

Naunyn Schmiedebergs Arch Pharmacol

ISSN

0028-1298

DOI

10.1007/BF00501230

Published

1979-11-00

Pages

203-5

Language

English

Region

Germany

NLM ID

0326264

Subset

External Links

PubMed source DOI: 10.1007/BF00501230 View journal details

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4,4'-Dihydroxyphenazone as an urinary metabolite of phenazone in different species including man.

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