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PMID: 5173260 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Syndrome of unilateral ectromelia, psoriasis and central nervous system anomalies.

Birth defects original article series ·Vol. 7 ·No. 8 ·1971-06-00 ·Pages 197-203

Shear CS, Nyhan WL, Frost P, Weinstein GD

Abstract

A patient presenting with unilateral ectromelia, psoriasiform dermatosis and central nervous system abnormalities has been studied. Four similar cases have been reported in the literature. Autoradiographic studies of the turnover rate of epidermal cells in the patient's affected skin revealed markedly increased proliferative activity which is consistent with the diagnosis of psoriasis. Also consistent with this diagnosis was the response to a therapeutic trial of systemic methotrexate.

MeSH Terms

Abnormalities, Multiple/genetics Autoradiography Birth Weight Cell Division Central Nervous System/abnormalities DNA/biosynthesis Ectromelia/genetics Female Functional Laterality Genes, Dominant Humans Infant Male Methotrexate/therapeutic use Musculoskeletal Abnormalities Pedigree Psoriasis/drug therapy,genetics Skin/metabolism Syndrome Thymidine/metabolism Tritium

Chemicals

Tritium DNA Thymidine Methotrexate

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Shear C S

Nyhan W L

Frost P

Weinstein G D

Article Info

Journal

Birth defects original article series

Abbr.

Birth Defects Orig Artic Ser

ISSN

0547-6844

Published

1971-06-00

Pages

197-203

Language

English

Region

United States

NLM ID

0003403

Subset

External Links

PubMed source

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Syndrome of unilateral ectromelia, psoriasis and central nervous system anomalies.

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