Lymphocyte-mediated cellular immunity in histoplasmosis.

Infection and immunity ·Vol. 4 ·No. 5 ·1971-11-00 ·Pages 605-10

Howard DH, Otto V, Gupta RK

Abstract

Mononuclear phagocytes freshly harvested from immunized animals restrict the intracellular growth of Histoplasma capsulatum, whereas the same cells maintained in culture for 48 hr do not. Experiments established that within the mixed cell population of the mouse peritoneal cavity the lymphocyte was the most likely mediator of the intracellular growth restriction observed. Partially purified lymphocytes, from the peritoneal cavity of mice immunized by sublethal infection, mediated the suppression of intracellular growth of the fungus in normal mouse macrophages in cell culture.

MeSH Terms

Animals Cattle/immunology Cells, Cultured Half-Life Histoplasma/growth & development,immunology Histoplasmosis/immunology Immune Sera Immunity, Cellular Lethal Dose 50 Lymphocytes/immunology Macrophages/immunology Mice Phagocytes/immunology Time Factors

Chemicals

Immune Sera

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Howard D H

Otto V

Gupta R K

References (14)

14 references, click to expand

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J Immunol. 1965 Apr;94:592-602 PMID: 14299035
Effect of temperature on the intracellular growth of Histoplasma capsulatum.
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The influence of immunologically committed lymphoid cells on macrophage activity in vivo.
J Exp Med. 1969 May 1;129(5):973-92 PMID: 4976110
Demonstration in tissue culture of lymphocyte-mediated immunity to tuberculosis.
Infect Immun. 1970 Jun;1(6):600-3 PMID: 16557782
Activation of normal rabbit macrophage monolayers by supernatants of antigen-stimulated lymphocytes.
J Immunol. 1970 Nov;105(5):1138-45 PMID: 5489068
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J Bacteriol. 1964 Jan;87:33-8 PMID: 14102870
Bactericidal Activity of Human Macrophages: Analysis of Factors Influencing the Killing of Listeria monocytogenes.
Infect Immun. 1970 Aug;2(2):156-61 PMID: 16557814
Resistance against Cryptococcus conferred by intracellular bacteria and protozoa.
J Infect Dis. 1971 Jan;123(1):22-31 PMID: 5543220
Effect of antilymphocyte serum on animals experimentally infected with Histoplasma capsulatum or Cryptococcus neoformans.
J Bacteriol. 1969 Dec;100(3):1271-6 PMID: 5361216
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J Immunol. 1960 Jul;85:6-13 PMID: 13852362
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Article Info

Journal

Infection and immunity

Abbr.

Infect Immun

ISSN

0019-9567

DOI

10.1128/iai.4.5.605-610.1971

Published

1971-11-00

Pages

605-10

Language

English

Region

United States

NLM ID

0246127

PMCID

PMC416360

Subset

External Links

PubMed source DOI: 10.1128/iai.4.5.605-610.1971 PMC Full Text View journal details

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Lymphocyte-mediated cellular immunity in histoplasmosis.

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