A new anti-oestrogenic agent in late breast cancer. An early clinical appraisal of ICI46474.

British journal of cancer ·Vol. 25 ·No. 2 ·1971-06-00 ·Pages 270-5

Cole MP, Jones CT, Todd ID

Abstract

An introductory clinical trial of the anti-oestrogenic agent IC146474 in late or recurrent carcinoma of the breast is described.Forty-six patients have been treated, of whom 10 have shown a good response. This is of the same order as that seen with oestrogens and androgens.The particular advantage of this drug is the low incidence of troublesome side effects.

MeSH Terms

Adult Aged Alkenes/therapeutic use Anabolic Agents/adverse effects,therapeutic use Breast Neoplasms/drug therapy Chronic Disease Diethylstilbestrol/adverse effects,therapeutic use Estrogen Antagonists Ethylamines/adverse effects,therapeutic use Female Humans Middle Aged Recurrence

Chemicals

Alkenes Anabolic Agents Estrogen Antagonists Ethylamines Diethylstilbestrol

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Cole M P

Jones C T

Todd I D

References (2)

2 references, click to expand

Role of estrogens in ovulation: A study using the estrogen-antagonist, I.C.I. 46,474.
Endocrinology. 1970 Sep;87(3):542-51 PMID: 5463820
New synthetic agent for the induction of ovulation: preliminary trials in women.
Br Med J. 1971 Jan 16;1(5741):152-4 PMID: 5539422

Article Info

Journal

British journal of cancer

Abbr.

Br J Cancer

ISSN

0007-0920

DOI

10.1038/bjc.1971.33

Published

1971-06-00

Pages

270-5

Language

English

Region

England

NLM ID

0370635

PMCID

PMC2008453

Subset

External Links

PubMed source DOI: 10.1038/bjc.1971.33 PMC Full Text View journal details

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A new anti-oestrogenic agent in late breast cancer. An early clinical appraisal of ICI46474.

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