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PMID: 5105387 Published · ppublish English Journal Article

Disturbed patterns of behaviour in morphine tolerant and abstinent rats.

British journal of pharmacology ·Vol. 42 ·No. 3 ·1971-07-00 ·Pages 473-84

Kumar R, Mitchell E, Stolerman IP

Abstract

1. Eating, drinking and spontaneous motor activity were studied in rats receiving large daily doses of morphine. These forms of behaviour were largely suppressed when the rats were made abstinent and were restored when morphine was given again.2. Compensation for depressions of behaviour during abstinence did not seem sufficient to account for all the stimulant effects of morphine in tolerant rats. Morphine also had slight stimulant actions in non-tolerant rats.3. In tolerant rats, the repeated pairing of the effects of morphine with the re-emergence of behaviour such as eating and drinking may intensify the rewarding value of the drug.

MeSH Terms
Animals Behavior, Animal/drug effects Circadian Rhythm/drug effects Drinking Behavior/drug effects Drug Tolerance Feeding Behavior/drug effects Humans Male Morphine/pharmacology Motor Activity/drug effects Rats Substance Withdrawal Syndrome
Chemicals
Morphine
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Kumar R
Mitchell E
Stolerman I P
References (27)
27 references, click to expand
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Article Info
Journal
British journal of pharmacology
Abbr.
Br J Pharmacol
ISSN
0007-1188
DOI
10.1111/j.1476-5381.1971.tb07132.x
Published
1971-07-00
Pages
473-84
Language
English
Region
England
NLM ID
7502536
PMCID
PMC1665671
Subset
IM
External Links
PubMed source DOI: 10.1111/j.1476-5381.1971.tb07132.x PMC Full Text View journal details
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