Lymphocyte DNA synthesis inhibition.

Science (New York, N.Y.) ·Vol. 173 ·No. 4002 ·1971-09-17 ·Pages 1139-41

Houck JC, Irausquin H, Leikin S

Abstract

A specific endogenous inhibitor for lymphocyte DNA synthesis that can be isolated from the lymphoid system and which is probably cell specific is described. The inhibitor is thermolabile, is destroyed by trypsin, and has a mass of about 30,000 to 50,000 daltons.

MeSH Terms

Animals Carbon Isotopes Cattle Child DNA/biosynthesis Fibroblasts/metabolism HeLa Cells/metabolism Humans Lectins/pharmacology Leukemia, Lymphoid/metabolism Lymph Nodes/analysis Lymphocytes/drug effects,metabolism Lymphoid Tissue/analysis Molecular Weight Phenylalanine/metabolism Rats Spleen/analysis Thymidine/metabolism Thymus Gland/analysis Tissue Extracts/pharmacology Tritium Uridine/metabolism

Chemicals

Carbon Isotopes Lectins Tissue Extracts Tritium Phenylalanine DNA Thymidine Uridine

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Houck J C

Irausquin H

Leikin S

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.173.4002.1139

Published

1971-09-17

Pages

1139-41

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.173.4002.1139 View journal details

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