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PMID: 50856 Published · ppublish English Comparative Study Journal Article

Differences in proliferative activity of rat and human prostate in culture.

British journal of cancer ·Vol. 31 ·No. 5 ·1975-05-00 ·Pages 570-80

Shipman PA, Littlewood V, Riches AC, Thomas GH

Abstract

The properties of human benign prostatic hyperplasia (BPH) and rat prostate were compared after culture in the absence of insulin and testosterone. Quantitative methods were used to assess changes in tissue composition and the height of the epithelial cells. BPH appeared less sensitive than rat prostate to withdrawal of hormone support, and the changes which occurred during culture of BPH were more typical of a repair mechanism to injury than of a castration effect. Cell kinetics was investigated using [125I] iododeoxyuridine and vincristine. Both approaches demonstrated a spontaneous surge in proliferative activity of BPH reaching a peak at about Day 4. In contrast, proliferative activity in rat prostate tended to fall over the period of 2-8 days of culture. The significance of these findings in terms of age linked effects is discussed.

MeSH Terms
Age Factors Animals Cell Differentiation Cell Division/drug effects Humans Insulin/pharmacology Kinetics Male Organ Culture Techniques Prostate/cytology Prostatic Hyperplasia/pathology Rats Testosterone/pharmacology
Chemicals
Insulin Testosterone
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Shipman P A
Littlewood V
Riches A C
Thomas G H
References (19)
19 references, click to expand
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Article Info
Journal
British journal of cancer
Abbr.
Br J Cancer
ISSN
0007-0920
DOI
10.1038/bjc.1975.98
Published
1975-05-00
Pages
570-80
Language
English
Region
England
NLM ID
0370635
PMCID
PMC2009448
Subset
IM
External Links
PubMed source DOI: 10.1038/bjc.1975.98 PMC Full Text View journal details
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