Variations in the responses of C57BL-10J and A-J mice to sheep red blood cells.

The Journal of experimental medicine ·Vol. 136 ·No. 5 ·1972-11-01 ·Pages 1063-71

Silver DM, McKenzie IF, Winn HJ

Abstract

In response to repeated injections of sheep red blood cells, C57BL/10J mice produce predominantly 19S antibody in increasingly higher amounts, while A/J mice initially produce 19S antibody and then switch to produce increasing 7S antibody titers. In an F(1) generation all mice responded like the C57BL/10J mice. Backcross data implied genetic control involving at least three loci.

MeSH Terms

Agglutinins/analysis Animals Antibody Formation Antibody Specificity Chromatography, Gel Erythrocytes/immunology Female Hemagglutination Tests Hemolysin Proteins/analysis Immunoglobulin Fragments Immunoglobulin G/biosynthesis Immunoglobulin M/biosynthesis Male Mice Mice, Inbred A Mice, Inbred C57BL Mice, Inbred Strains/immunology Sheep/immunology

Chemicals

Agglutinins Hemolysin Proteins Immunoglobulin Fragments Immunoglobulin G Immunoglobulin M

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Silver D M

McKenzie I F

Winn H J

References (6)

6 references, click to expand

Thymus-marrow cell combinations. Synergism in antibody production.
Proc Soc Exp Biol Med. 1966 Aug-Sep;122(4):1167-71 PMID: 5918139
Genetic control of specific immune responses.
Adv Immunol. 1969;11:31-74 PMID: 4908392
Incidence of cells simultaneously secreting IgM and IgG antibody to sheep erythrocytes.
Cell Immunol. 1971 Feb;2(1):41-53 PMID: 4940896
Interaction between lymphocytes in immune responses.
Cell Immunol. 1971 Oct;2(5):469-95 PMID: 4399419
Individual antigenic specificity in immunoglobulins: relationship to biosynthesis.
Fed Proc. 1972 Jan-Feb;31(1):206-9 PMID: 4109799
THE HETEROGENEITY OF THE IMMUNE RESPONSE.
Science. 1964 Jul 31;145(3631):457-64 PMID: 14163764

Article Info

Journal

The Journal of experimental medicine

Abbr.

J Exp Med

ISSN

0022-1007

DOI

10.1084/jem.136.5.1063

Published

1972-11-01

Pages

1063-71

Language

English

Region

United States

NLM ID

2985109R

PMCID

PMC2139309

Subset

External Links

PubMed source DOI: 10.1084/jem.136.5.1063 PMC Full Text View journal details

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Variations in the responses of C57BL-10J and A-J mice to sheep red blood cells.

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