Resistance of Staphylococcus aureus to sulphamethoxazole and trimethoprim.

Journal of clinical pathology ·Vol. 25 ·No. 8 ·1972-08-00 ·Pages 708-12

Nakhla LS

Abstract

Strains of Staphylococcus aureus isolated from the lesions of hospital patients were surveyed for resistance to sulphamethoxazole and to trimethoprim. Of 675 strains tested, 18.5% were resistant to sulphamethoxazole and 1.6% to trimethoprim. All the trimethoprim-resistant strains were resistant to sulphamethoxazole and to a 1:20 mixture of the two drugs. Trimethoprim-resistant strains were on average more resistant to sulphamethoxazole than were trimethoprim-sensitive strains. They were all resistant to several other antimicrobial agents. Most of them had the phage-typing pattern 84/85, 84, or 85.

MeSH Terms

Anti-Bacterial Agents/pharmacology Bacitracin/pharmacology Bacteriophage Typing Drug Resistance, Microbial Folic Acid Antagonists/pharmacology Fusidic Acid/pharmacology Humans Lincomycin/pharmacology Microbial Sensitivity Tests Neomycin/pharmacology Oleandomycin Penicillin Resistance Pyrimidines/pharmacology Staphylococcus/drug effects Streptomycin/pharmacology Sulfamethoxazole/pharmacology Sulfonamides/pharmacology Tetracycline/pharmacology Trimethoprim/pharmacology

Chemicals

Anti-Bacterial Agents Folic Acid Antagonists Pyrimidines Sulfonamides Bacitracin Fusidic Acid Trimethoprim Lincomycin Tetracycline Neomycin Sulfamethoxazole Oleandomycin Streptomycin

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Nakhla L S

References (11)

11 references, click to expand

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Article Info

Journal

Journal of clinical pathology

Abbr.

J Clin Pathol

ISSN

0021-9746

DOI

10.1136/jcp.25.8.708

Published

1972-08-00

Pages

708-12

Language

English

Region

England

NLM ID

0376601

PMCID

PMC477483

Subset

External Links

PubMed source DOI: 10.1136/jcp.25.8.708 PMC Full Text View journal details

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Resistance of Staphylococcus aureus to sulphamethoxazole and trimethoprim.

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