Induction of deoxyribonucleic acid synthesis and the oncogenicity of Marek's disease virus.

Journal of virology ·Vol. 10 ·No. 2 ·1972-08-00 ·Pages 167-70

Lee LF

Abstract

Leukocytes recovered from birds inoculated with an oncogenic strain of Marek's disease virus synthesized deoxyribonucleic acid in vitro at a rate 7.9 times that of leukocytes from normal birds or birds inoculated with the nononcogenic herpesvirus of turkeys. A close relationship was observed between the level of in vitro deoxyribonucleic acid synthesis and in vivo tumor formation.

MeSH Terms

Animals Carbon Isotopes Centrifugation, Density Gradient Chickens Culture Techniques DNA/analysis,biosynthesis Herpesviridae/isolation & purification,pathogenicity Leukocytes/analysis,metabolism,microbiology Marek Disease/blood,microbiology Neoplasms/epidemiology,veterinary Thymidine/metabolism Tritium Ultracentrifugation

Chemicals

Carbon Isotopes Tritium DNA Thymidine

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Lee L F

References (11)

11 references, click to expand

Size and composition of Marek's disease virus deoxyribonucleic acid.
J Virol. 1971 Mar;7(3):289-94 PMID: 4101222
Isolation from turkeys of a cell-associated herpesvirus antigenically related to Marek's disease virus.
Am J Vet Res. 1970 Mar;31(3):525-38 PMID: 4314928
Pathogenicity and Antigenicity of Clones from Strains of Marek's Disease Virus and the Herpesvirus of Turkeys.
Infect Immun. 1971 Feb;3(2):295-303 PMID: 16557968
A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid.
Biochem J. 1956 Feb;62(2):315-23 PMID: 13293190
Induction of cellular DNA synthesis in human leukocytes by Epstein-Barr virus.
Nature. 1971 May 7;231(5297):46-7 PMID: 4325099
Studies on the etiology of Marek's disease. II. Finding of a herpesvirus in cell culture.
Proc Soc Exp Biol Med. 1968 Jan;127(1):177-82 PMID: 5644640
Stimulation of DNA synthesis in human and hamster cells by human adenovirus types 12 and 5.
Proc Soc Exp Biol Med. 1966 Jul;122(3):740-6 PMID: 5918942
Protection against Marek's disease by vaccination with a herpesvirus of turkeys.
Avian Dis. 1970 May;14(2):413-29 PMID: 4913403
Large-scale production of Marek's disease virus.
Avian Dis. 1971 Jul-Sep;15(3):565-71 PMID: 4329206
INDUCTION OF CELLULAR DNA SYNTHESIS BY POLYOMA VIRUS.
Proc Natl Acad Sci U S A. 1965 Feb;53:403-10 PMID: 14294074
Cell-free transmission and in vivo replication of Marek's disease virus.
J Virol. 1970 Mar;5(3):388-97 PMID: 4191324

Article Info

Journal

Journal of virology

Abbr.

J Virol

ISSN

0022-538X

DOI

10.1128/JVI.10.2.167-170.1972

Published

1972-08-00

Pages

167-70

Language

English

Region

United States

NLM ID

0113724

PMCID

PMC356446

Subset

External Links

PubMed source DOI: 10.1128/JVI.10.2.167-170.1972 PMC Full Text View journal details

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Induction of deoxyribonucleic acid synthesis and the oncogenicity of Marek's disease virus.

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