An explanation of the antiandrogenic properties of 6 -bromo-17 -hydroxy-17 -methyl-4-oxa-5 -androstane-3-one.

Aldosterone/pharmacology Androgen Antagonists Androstanes/pharmacology Animals Binding Sites Bromine Castration Cell Nucleus/drug effects,enzymology Cell-Free System Corticosterone/pharmacology Cyproterone/pharmacology Cytoplasm/drug effects DNA-Directed RNA Polymerases/metabolism Ketosteroids/pharmacology Male Oxidoreductases/metabolism Prostate/enzymology Protein Binding/drug effects Rats Testosterone/metabolism Tritium

Androgen Antagonists Androstanes Ketosteroids Tritium Testosterone Aldosterone Cyproterone Oxidoreductases DNA-Directed RNA Polymerases Bromine Corticosterone